Effect of Heat Stimulation on Circulating Irisin in Humans
Park TH, Lee HJ, Lee JB
Frontiers in physiology · 12 citations
How it was studied
- Design
- Controlled clinical trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- National Research Foundation
- University or hospital
- Soonchunhyang University
- Government
- National Research Foundation of Korea
- Grants
- National Research Foundation (No. 2016R1D1A3B02015394); National Research Foundation of Korea (2016R1D1A3B02015394)
Based on 3 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2021-06-28 · Front Physiol · vol. 12 · p. 675377
- Publisher
- Frontiers Media
- Cited
- 14 citations · more than 74% of similar papers · 1.0× the field average
- References
- 37 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Adipose Tissue and Metabolism · Thermoregulation and physiological responses · Exercise and Physiological Responses
- Keywords
- Stimulation, Medicine, Endocrinology, Internal medicine, Biology, Neuroscience
3 authors
From KR
- Tae Hwan ParkSoonchunhyang University
- Hye-Jin LeeSoonchunhyang University
- Jeong‐Beom Lee · correspondingSoonchunhyang University
Abstract
High temperatures lead to oxidative stress. The aim of the study was to determine whether heat stimulation-induced hyperthermia can increase the level of circulating irisin. Twenty-one healthy female subjects (age, 26.3 ± 2.71 years; height, 162.1 ± 3.15 cm; weight, 54.2 ± 3.86 kg; and body surface area, 1.57 ± 0.11 m2) not taking contraceptives participated in this study. All experiments were performed individually for each participant when they were in the early proliferative menstrual phase. In an automated climate chamber (25 ± 0.5°C), the heat load was applied via half-body immersion into a hot water bath (42 ± 0.5°C). Five-minutes break was provided every after 5 min of immersion and the total passive heating time was 30 min. Tympanic temperature (Tt y) and skin temperature (Ts) were measured. Mean body temperature (mTb) was calculated. Blood samples were collected before and immediately after immersion. Levels of irisin, cortisol, creatine kinase (CK), and lactate dehydrogenase (LDH) were analyzed. Tty, mTb and serum irisin levels increased after hot water immersion. The blood levels of cortisol, CK, and LDH were also elevated after hot water immersion. Heat stimulation might increase the levels of circulating irisin in humans in response to oxidative stress.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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