Associations of Whole Grain and Refined Grain Consumption With Metabolic Syndrome. A Meta-Analysis of Observational Studies
Guo H, Ding J, Liang J, Zhang Y
Frontiers in nutrition · 31 citations
How it was studied
- Design
- Systematic review (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- University or hospital
- Central South University
- University or hospital
- Xiangya Hospital, Central South University
- Grants
- Xiangya Hospital, Central South University (2020Q14); Central South University (2020Q14)
Based on 2 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2021-07-01 · Front Nutr · vol. 8 · p. 695620
- Publisher
- Frontiers Media
- Cited
- 48 citations · more than 88% of similar papers · 2.2× the field average
- References
- 50 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Nutritional Studies and Diet · Nutrition, Genetics, and Disease · Diet, Metabolism, and Disease
- Keywords
- Observational study, Medicine, Confidence interval, Whole grains, Cohort study, Relative risk, Consumption (sociology), Prospective cohort study, Epidemiology, Refined grains, Meta-analysis, Metabolic syndrome, Demography, Environmental health, Internal medicine, Food science, Obesity, Biology
4 authors
From CN
- Hongbin GuoCentral South University; Xiangya Hospital Central South University
- Jun DingChangsha University
- Jieyu LiangCentral South University; Xiangya Hospital Central South University
- Yi Zhang · correspondingCentral South University; Xiangya Hospital Central South University
Abstract
Background: The associations of whole grain and refined grain consumption with metabolic syndrome (MetS) has been evaluated in several epidemiological studies with conflicting results. This meta-analysis was therefore employed to further investigate the above associations. Method: We searched the PubMed, Web of Science and Embase database until March 2021 (without restriction for inclusion time), for observational studies on the associations of whole grain and refined grain consumption with MetS. The pooled relative risk (RR) of MetS for the highest vs. lowest category of whole grain and refined grain consumption, as well as their corresponding 95% confidence interval (CI) were calculated. Results: A total of 14 observational studies, which involved seven cross-sectional and seven prospective cohort studies, were identified. Specifically, nine studies were related to whole grain consumption, and the overall multi-variable adjusted RR demonstrated that the whole grain consumption was inversely associated with MetS (RR = 0.80, 95%CI: 0.67-0.97; P = 0.021). With regard to refined grain consumption, 13 studies were included. The overall multi-variable adjusted RR indicated that refined grain consumption was positively associated with MetS (RR = 1.37, 95%CI: 1.02-1.84; P = 0.036). Conclusions: The existing evidence suggests that whole grain consumption is negatively associated with MetS, whereas refined grain consumption is positively associated with MetS. Our result might be helpful to better consider the diet effect on MetS. However, more well-designed prospective cohort studies are needed to elaborate the concerned issues further.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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