Acute Effects of Dietary Nitrate on Exercise Tolerance, Muscle Oxygenation, and Cardiovascular Function in Patients With Peripheral Arterial Disease
van der Avoort CMT, van Loon LJC, Verdijk LB, Poyck PPC, Thijssen DTJ, Hopman MTE
International journal of sport nutrition and exercise metabolism · 13 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Food provided by researchers
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2021-07-20 · Int J Sport Nutr Exerc Metab · vol. 31 · issue 5 · pp. 385–396
- Publisher
- Human Kinetics
- Cited
- 18 citations · more than 91% of similar papers · 2.7× the field average
- Impact
- Top 10% most cited in its field
- References
- 60 works
- Access
- Paywalled
- Research areas
- Peripheral Artery Disease Management · Cardiovascular Health and Disease Prevention · Cerebrovascular and Carotid Artery Diseases
- Keywords
- Medicine, Arterial stiffness, Nitrate, Blood pressure, Claudication, Crossover study, Placebo, Cardiology, Oxygenation, Nitrite, Internal medicine, Dietary Nitrate, Surgery, Arterial disease, Chemistry, Vascular disease, Pathology
- MeSH
- muscle, skeletal, humans, beta vulgaris, nitrates, cross-over studies, double-blind method, blood pressure, exercise tolerance, dietary supplements, aged, aged, 80 and over, peripheral arterial disease, fruit and vegetable juices
6 authors
From NL, US, GB
- Cindy M.T. van der AvoortHAN University of Applied Sciences; Radboud University Nijmegen; Maastricht University Medical Centre; University Medical Center; Radboud University Medical Center
- Luc J. C. van LoonHAN University of Applied Sciences; Maastricht University Medical Centre
- Lex B. VerdijkMaastricht University Medical Centre
- Paul P. C. Poyck
- Dick T.J. ThijssenRadboud University Nijmegen; University Medical Center; Radboud University Medical Center; Liverpool John Moores University
- Maria T. E. HopmanRadboud University Nijmegen; University Medical Center; Radboud University Medical Center
Abstract
Previous studies have used supplements to increase dietary nitrate intake in clinical populations. Little is known about whether effects can also be induced through vegetable consumption. Therefore, the aim of this study was to assess the impact of dietary nitrate, through nitrate-rich vegetables (NRV) and beetroot juice (BRJ) supplementation, on plasma nitrate and nitrite concentrations, exercise tolerance, muscle oxygenation, and cardiovascular function in patients with peripheral arterial disease. In a randomized crossover design, 18 patients with peripheral arterial disease (age: 73 ± 8 years) followed a nitrate intake protocol (∼6.5 mmol) through the consumption of NRV, BRJ, and nitrate-depleted BRJ (placebo). Blood samples were taken, blood pressure and arterial stiffness were measured in fasted state and 150 min after intervention. Each intervention was followed by a maximal walking exercise test to determine claudication onset time and peak walking time. Gastrocnemius oxygenation was measured by near-infrared spectroscopy. Blood samples were taken and blood pressure was measured 10 min after exercise. Mean plasma nitrate and nitrite concentrations increased (nitrate; Time × Intervention interaction; p < .001), with the highest concentrations after BRJ (494 ± 110 μmol/L) compared with NRV (202 ± 89 μmol/L) and placebo (80 ± 19 μmol/L; p < .001). Mean claudication onset time and peak walking time did not differ between NRV (413 ± 187 s and 745 ± 220 s, respectively), BRJ (392 ± 154 s and 746 ± 176 s), and placebo (403 ± 176 s and 696 ± 222 s) (p = .762 and p = .165, respectively). Gastrocnemius oxygenation, blood pressure, and arterial stiffness were not affected by the intervention. NRV and BRJ intake markedly increase plasma nitrate and nitrite, but this does not translate to improved exercise tolerance, muscle oxygenation, and/or cardiovascular function.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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