Effect of Intermittent Fasting on Non-Alcoholic Fatty Liver Disease: Systematic Review and Meta-Analysis
Yin C, Li Z, Xiang Y, Peng H, Yang P, Yuan S, Zhang X, Wu Y, Huang M, Li J
Frontiers in nutrition · 53 citations
How it was studied
- Design
- Systematic review (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- National Natural Science Foundation of China
- Government
- Natural Science Foundation of Hubei Province
- Grants
- Natural Science Foundation of Hubei Province (2060302); National Natural Science Foundation of China (2060302)
Based on 2 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2021-07-12 · Front Nutr · vol. 8 · p. 709683
- Publisher
- Frontiers Media
- Cited
- 74 citations · more than 92% of similar papers · 2.5× the field average
- Impact
- Top 10% most cited in its field
- References
- 34 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Dietary Effects on Health · Liver Disease Diagnosis and Treatment · Diet, Metabolism, and Disease
- Keywords
- Medicine, Fatty liver, Internal medicine, Cochrane Library, Meta-analysis, Transaminase, Gastroenterology, Alanine transaminase, Weight loss, Body mass index, Intermittent fasting, Aspartate transaminase, Steatosis, Endocrinology, Disease, Obesity, Alkaline phosphatase, Enzyme, Biochemistry, Chemistry
10 authors
From CN
- Cong YinHubei University of Chinese Medicine
- Zihan LiHubei University of Chinese Medicine
- Yulin XiangHubei University of Chinese Medicine
- Hongbing PengHubei University of Chinese Medicine
- Ping Chang YangHubei University of Chinese Medicine
- Shijun YuanHubei University of Chinese Medicine
Abstract
Background: Weight loss by lifestyle modification is the cornerstone therapy of non-alcoholic fatty liver disease (NAFLD). Intermittent fasting has shown favorable effects on body weight (BW) and relevant indicators of NAFLD in several reports. Objective: To estimate the effects of intermittent fasting on adults with NAFLD. Materials and methods: Literature searches were conducted on PubMed, EMBASE, Web of Science, Cochrane Library, and ClinicalTrials.gov from inception to May 10, 2021. Results: A total of six studies involving 417 patients with NAFLD were included. In the meta-analysis, there were significant differences in BW, body mass index (BMI), alanine aminotransferase (ALT), and aspartate transaminase (AST) between the control and fasting group. Up to now, there is no significant difference in triglycerides (TG), total cholesterol (TC), and other metabolic parameters between the two groups. Conclusions: Intermittent fasting is beneficial for weight management and liver enzyme improvement, but long-term feasibility and safety of intermittent fasting should be conducted in further studies.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.