Sauna dehydration as a new physiological challenge model for intestinal barrier function
Roca Rubio MF, Eriksson U, Brummer RJ, König J
Scientific reports · 14 citations
How it was studied
- Design
- Randomized controlled trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- University or hospital
- Örebro Universitet
- Nonprofit
- Knowledge Foundation
- University or hospital
- Örebro University
Based on 3 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2021-07-30 · Sci Rep · vol. 11 · issue 1 · p. 15514
- Publisher
- Nature Portfolio
- Cited
- 15 citations · more than 80% of similar papers · 1.4× the field average
- References
- 76 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Dietary Effects on Health · Thermoregulation and physiological responses · Diet and metabolism studies
- Keywords
- Intestinal permeability, Barrier function, Dehydration, Lipopolysaccharide, In vivo, Internal medicine, Lipopolysaccharide binding protein, Chemistry, Tight junction, Medicine, Endocrinology, Inflammation, Biochemistry, Biology, Acute-phase protein, Cell biology
- MeSH
- liver, humans, tumor necrosis factor-alpha, acute-phase proteins, carrier proteins, membrane glycoproteins, anti-inflammatory agents, non-steroidal, interleukin-6, interleukin-10, steam bath, temperature, biomedical research, adult, female, male, fatty acid-binding proteins, young adult, lipopolysaccharide-binding protein
4 authors
From SE
- Maria Fernanda Roca Rubio · correspondingÖrebro University
- Ulrika ErikssonÖrebro University
- Robert J. BrummerÖrebro University
- Julia KönigÖrebro University
Abstract
The intestinal barrier plays a crucial role in maintaining gut health, and an increased permeability has been linked to several intestinal and extra-intestinal disorders. There is an increasing demand for interventions aimed at strengthening this barrier and for in vivo challenge models to assess their efficiency. This study investigated the effect of sauna-induced dehydration on intestinal barrier function (clinicaltrials.gov: NCT03620825). Twenty healthy subjects underwent three conditions in random order: (1) Sauna dehydration (loss of 3% body weight), (2) non-steroidal anti-inflammatory drug (NSAID) intake, (3) negative control. Intestinal permeability was assessed by a multi-sugar urinary recovery test, while intestinal damage, bacterial translocation and cytokines were assessed by plasma markers. The sauna dehydration protocol resulted in an increase in gastroduodenal and small intestinal permeability. Presumably, this increase occurred without substantial damage to the enterocytes as plasma intestinal fatty acid-binding protein (I-FABP) and liver fatty acid-binding protein (L-FABP) were not affected. In addition, we observed significant increases in levels of lipopolysaccharide-binding protein (LBP), IL-6 and IL-8, while sCD14, IL-10, IFN-ɣ and TNF-α were not affected. These results suggest that sauna dehydration increased intestinal permeability and could be applied as a new physiological in vivo challenge model for intestinal barrier function.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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