Effects of the Mediterranean Diet or Nut Consumption on Gut Microbiota Composition and Fecal Metabolites and their Relationship with Cardiometabolic Risk Factors
Galié S, García-Gavilán J, Camacho-Barcía L, Atzeni A, Muralidharan J, Papandreou C, Arcelin P, Palau-Galindo A, Garcia D, Basora J, Arias-Vasquez A, Bulló M
Molecular nutrition & food research · 34 citations
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- Government
- Agència de Gestió d'Ajuts Universitaris i de Recerca
- Government
- Instituto de Salud Carlos III
- Government
- H2020 Marie Skłodowska-Curie Actions
- Government
- Agència de Gestió d'Ajuts Universitaris i de Recerca
- Grants
- Instituto de Salud Carlos III (CP 19/00189); Agència de Gestió d'Ajuts Universitaris i de Recerca (2018FI_B_00444); Agència de Gestió d'Ajuts Universitaris i de Recerca (FI-DGR 2017); Instituto de Salud Carlos III (PFIS FI17/00255); H2020 Marie Skłodowska-Curie Actions (713679)
Based on 4 listed funder(s).
Publication
- Published
- 2021-07-31 · Mol Nutr Food Res · vol. 65 · issue 19 · p. e2000982
- Publisher
- Wiley
- Cited
- 52 citations · more than 96% of similar papers · 4.9× the field average
- Impact
- Top 10% most cited in its field
- References
- 38 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Nuts composition and effects · Nutritional Studies and Diet · Agriculture Sustainability and Environmental Impact
- Keywords
- Lachnospiraceae, Insulin resistance, Mediterranean diet, Gut flora, Food science, Metabolic syndrome, Feces, Biology, Insulin, Medicine, Internal medicine, Endocrinology, Diabetes mellitus, Biochemistry, Microbiology, Firmicutes
- MeSH
- feces, humans, nuts, insulin, diet, mediterranean, middle aged, metabolome, gastrointestinal microbiome, cardiometabolic risk factors
12 authors
From ES, NL
- Serena GaliéInstituto de Salud Carlos III; Institut Pere Mata; Institut de Recerca Biomèdica Catalunya Sud; Universitat Rovira i Virgili
- Jesús Francisco García-GavilánInstituto de Salud Carlos III; Institut Pere Mata; Institut de Recerca Biomèdica Catalunya Sud; Universitat Rovira i Virgili
- Lucía Camacho‐BarciaInstituto de Salud Carlos III; Institut Pere Mata; Institut de Recerca Biomèdica Catalunya Sud; Universitat Rovira i Virgili
- Alessandro AtzeniInstituto de Salud Carlos III; Institut Pere Mata; Institut de Recerca Biomèdica Catalunya Sud; Universitat Rovira i Virgili
- Jananee MuralidharanInstituto de Salud Carlos III; Institut Pere Mata; Institut de Recerca Biomèdica Catalunya Sud; Universitat Rovira i Virgili
- Christopher PapandreouInstituto de Salud Carlos III; Institut Pere Mata; Institut de Recerca Biomèdica Catalunya Sud; Universitat Rovira i Virgili
Abstract
Scope
To examine whether a Mediterranean Diet (MedDiet) compared to the consumption of nuts in the context of a habitual non-MedDiet exerts a greater beneficial effect on gut microbiota and fecal metabolites; thus, contributing to explain major benefits on cardiometabolic risk factors.
Methods and results
Fifty adults with Metabolic Syndrome are randomized to a controlled, crossover 2-months dietary-intervention trial with a 1-month wash-out period, following a MedDiet or consuming nuts (50 g day-1 ). Microbiota composition is assessed by 16S rRNA gene sequencing and metabolites are measured using Nuclear Magnetic Resonance (NMR) and liquid chromatography coupled to triple quadrupole mass spectrometry (LC-qTOF) platforms in a targeted metabolomics approach. Decreased glucose, insulin and the homeostatic model assessment of insulin resistance (HOMA-IR) is observed after the MedDiet compared to the nuts intervention. Relative abundances of Lachnospiraceae NK4A136 and an uncultured genera of Ruminococcaceae are significantly increased after the MedDiet compared to nuts supplementation. Changes in Lachnospiraceae NK4A136 are inversely associated with insulin levels and HOMA-IR, while positively and negatively with changes in cholate and cadaverine, respectively.
Conclusions
Following a MedDiet, rather than nuts, induces a significant increase in Lachnospiraceae NK4A136 and improves the metabolic risk. This genera seems to affect the bile acid metabolism and cadaverine which may account for the improvement in insulin levels.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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