Ultra-processed food intake and all-cause mortality: DRECE cohort study
Romero Ferreiro C, Martín-Arriscado Arroba C, Cancelas Navia P, Lora Pablos D, Gómez de la Cámara A
Public health nutrition · 39 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Independent funding
- Government
- Instituto de Salud Carlos III
- Grants
- Instituto de Salud Carlos III (P-MMA2004/19); Instituto de Salud Carlos III (P-MMA2008/88); Instituto de Salud Carlos III (FIS 03/0014); Instituto de Salud Carlos III (FIS 08/90643)
Based on 1 listed funder(s).
Publication
- Published
- 2021-08-05 · Public Health Nutr · vol. 25 · issue 7 · pp. 1854–1863
- Publisher
- Cambridge University Press
- Cited
- 58 citations · more than 98% of similar papers · 8.5× the field average
- Impact
- Top 10% most cited in its field
- References
- 66 works
- Access
- Open access (hybrid journal) · CC-BY-NC-SA
- Research areas
- Consumer Attitudes and Food Labeling · Global Public Health Policies and Epidemiology · Nutrition, Genetics, and Disease
- Keywords
- Medicine, Hazard ratio, Cohort, Proportional hazards model, Cohort study, Population, Confidence interval, Environmental health, Prospective cohort study, Risk of mortality, Demography, Food group, Internal medicine
5 authors
From ES
- Carmen Romero · correspondingHospital Universitario 12 De Octubre; Spanish Clinical Research Network
- Cristina Martín‐Arriscado ArrobaHospital Universitario 12 De Octubre; Spanish Clinical Research Network
- Pilar Cancelas NaviaHospital Universitario 12 De Octubre; Spanish Clinical Research Network
- David Lora PablosUniversidad Complutense de Madrid; Hospital Universitario 12 De Octubre; Spanish Clinical Research Network; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
- Agustı́n Gómez de la CámaraHospital Universitario 12 De Octubre; Spanish Clinical Research Network; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Abstract
Objective
To determine the association between ultra-processed food (UPF) intake and all-cause mortality in a representative sample of Spanish population.
Design
Prospective cohort design in which follow-up lasted from baseline (1991) to mortality date or 31 December 2017, whichever was first. Dietary information was collected using a validated frequency questionnaire and categorised following the NOVA classification according to the extent of food processing. The association between consumption of UPF and mortality was analysed using Cox models. Isoenergetic substitution models were constructed to compare the health effects of the NOVA groups.
Setting
Cohort from the Diet and Risk of Cardiovascular Diseases (CVD) in Spain (DRECE) study, representative of the Spanish population.
Participants
Totally, 4679 subjects between 5 and 59 years old.
Results
Average consumption of UPF was 370·8 g/d (24·4 % of energy intake). After a median follow-up of 27 years, 450 deaths occurred. Those who consumed the highest amount of UPF had higher risk of mortality. For every 10 % of the energy intake from UPF consumption, an increase of 15 % in the hazard of all-cause mortality was observed (HR 1·15; (95 % CI 1·03, 1·27); P-value = 0·012). Substitution of UPF with minimally processed foods was significantly associated with a decreased risk of mortality.
Conclusions
An increase in UPF consumption was associated with higher risk of all-cause mortality in a representative sample of the Spanish population. Moreover, the theoretical substitution of UPF with unprocessed or minimally processed foods leads to a decrease in mortality. These results support the need to promote diets based on unprocessed or minimally processed foods.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-SA).
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