Whole-Body Cryotherapy Increases the Activity of Nitric Oxide Synthase in Older Men
Wiecek M, Szygula Z, Gradek J, Kusmierczyk J, Szymura J
Biomolecules · 11 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Controlled clinical trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Mechanisms only
Who paid for it
- Funding
- Independent funding
- University or hospital
- University of Physical Education in Kraków, Poland
Based on 1 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2021-07-16 · Biomolecules · vol. 11 · issue 7 · p. 1041
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 17 citations · more than 82% of similar papers · 1.3× the field average
- References
- 58 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Exercise and Physiological Responses · Cardiovascular and exercise physiology · Thermoregulation and physiological responses
- Keywords
- Asymmetric dimethylarginine, Oxidative stress, Nitrotyrosine, Internal medicine, Nitric oxide synthase, Nitric oxide, Homocysteine, Endocrinology, Inflammation, Medicine, Chemistry, Biochemistry, Arginine
- MeSH
- humans, arginine, tyrosine, interleukins, body mass index, exercise, cryotherapy, oxidative stress, physical endurance, aged, middle aged, male, nitric oxide synthase type ii, athletes
5 authors
From PL
- Magdalena Więcek · correspondingUniversity of Physical Culture in Kraków
- Zbigniew SzygułaUniversity of Physical Culture in Kraków
- Joanna GradekUniversity of Physical Culture in Kraków
- Justyna KuśmierczykUniversity of Physical Culture in Kraków
- Jadwiga Szymura · correspondingUniversity of Physical Culture in Kraków
Abstract
Aging causes oxidative stress, endothelial dysfunction and a reduction in the bioavailability of nitric oxide. The study aim was to determine whether, as a result of repeated whole-body exposure to cryogenic temperature (3 min -130 °C), there is an increase of inducible nitric oxide synthase (iNOS) concentration in senior subjects (59 ± 6 years), and if this effect is stronger in athletes. In 10 long-distance runners (RUN) and 10 untraining (UTR) men, 24 whole-body cryotherapy (WBC) procedures were performed. Prior to WBC, after 12th and 24th treatments and 7 days later, the concentration of iNOS, asymmetric dimethylarginine (ADMA), 3-nitrotyrosine (3-NTR), homocysteine (HCY), C-reactive protein (CRP) and interleukins such as: IL-6, IL-1β, IL-10 were measured. In the RUN and UTR groups, after 24 WBC, iNOS concentration was found to be comparable and significantly higher (F = 5.95, p p > 0.05). As a result of applying 24 WBC treatments, using the every-other-day model, iNOS concentration increased in the group of older men, regardless of their physical activity level. Along with this increase, there were no changes in nitro-oxidative stress or inflammation marker levels.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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