Sclerostin and bone remodeling biomarkers responses to whole-body cryotherapy (- 110 °C) in healthy young men with different physical fitness levels
Straburzyńska-Lupa A, Cisoń T, Gomarasca M, Babińska A, Banfi G, Lombardi G, Śliwicka E
Scientific reports · 5 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Controlled clinical trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Mechanisms only
Who paid for it
- Funding
- Independent funding
- Government
- Narodowe Centrum Nauki
- Grants
- Narodowe Centrum Nauki (2017/25/B/NZ7/02309)
Based on 1 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2021-08-09 · Sci Rep · vol. 11 · issue 1 · p. 16156
- Publisher
- Nature Portfolio
- Cited
- 8 citations · more than 71% of similar papers · 0.7× the field average
- References
- 58 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Exercise and Physiological Responses · Heat shock proteins research · Infrared Thermography in Medicine
- Keywords
- Sclerostin, Osteoprotegerin, Osteocalcin, Internal medicine, Endocrinology, Medicine, Bone remodeling, Cryotherapy, N-terminal telopeptide, RANKL, Receptor, Activator (genetics), Chemistry, Alkaline phosphatase, Surgery, Biochemistry, Signal transduction
- MeSH
- bone and bones, humans, collagen type i, peptides, adaptor proteins, signal transducing, osteocalcin, cryotherapy, bone remodeling, energy metabolism, physical fitness, male, rank ligand, osteoprotegerin, young adult, biomarkers
7 authors
From PL, IT, HU
- Anna Straburzyńska‐LupaUniversity of Physical Culture in Kraków
- Tomasz CisońPaństwowa Wyższa Szkoła Zawodowa w Nowym Sączu
- Marta GomarascaIRCCS Ospedale Galeazzi - Sant'Ambrogio
- Anna BabińskaGdańsk Medical University
- Giuseppe BanfiVita-Salute San Raffaele University; IRCCS Ospedale Galeazzi - Sant'Ambrogio
- Giovanni LombardiIRCCS Ospedale Galeazzi - Sant'Ambrogio
Abstract
We investigated the effects of single and repeated exposures to whole-body cryotherapy on biomarkers of bone remodeling and osteo-immune crosstalk: sclerostin, osteocalcin (OC), C-terminal cross-linked telopeptide of type I collagen (CTx-I), osteoprotegerin (OPG) and free soluble receptor activator for nuclear factor κ B ligand (sRANKL). The study included 22 healthy males, grouped in high physical fitness level (HPhL) and low physical fitness level (LPhL), all undergone 10 consecutive sessions in a cryogenic chamber (- 110 °C). We observed a significant time-effect on sclerostin (p < 0.05), OC (p < 0.01), CTx-I (p < 0.001), OC/CTx-I (p < 0.05), and significant differences in sRANKL between the groups (p < 0.05) after the 1st cryostimulation; a significant time-effect on OC (p < 0.001) and OC/CTx-I (p < 0.001) after the 10th cryostimulation, and a significant time-effect on CTx-I (p < 0.001) and OC/CTx-I (p < 0.01) after 10 sessions of WBC. In conclusion, in young men, the first exposure to extreme cold induced significant changes in serum sclerostin. The changes in sRANKL, between groups, suggest that fitness level may modify the body's response to cold. The effects of the first stimulus and the whole session are not identical, probably due to the physiological development of habituation to cold.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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