The Effects of Vitamin D Supplementation and 25-Hydroxyvitamin D Levels on the Risk of Myocardial Infarction and Mortality
Acharya P, Dalia T, Ranka S, Sethi P, Oni OA, Safarova MS, Parashara D, Gupta K, Barua RS
Journal of the Endocrine Society · 57 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Case-control study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2021-07-15 · J Endocr Soc · vol. 5 · issue 10 · p. bvab124
- Publisher
- Endocrine Society
- Cited
- 75 citations · more than 99% of similar papers · 8.5× the field average
- Impact
- Top 10% most cited in its field
- References
- 31 works
- Access
- Open access (journal) · CC-BY-NC-ND
- Research areas
- Vitamin D Research Studies · Cardiac Imaging and Diagnostics · HIV-related health complications and treatments
- Keywords
- Medicine, Myocardial infarction, Hazard ratio, Internal medicine, Vitamin D and neurology, Proportional hazards model, Gastroenterology, Propensity score matching, vitamin D deficiency, Group B, Confidence interval
9 authors
From US
- Prakash AcharyaUniversity of Kansas Medical Center
- Tarun DaliaUniversity of Kansas Medical Center
- Sagar RankaUniversity of Kansas Medical Center
- Prince SethiUniversity of Kansas Medical Center
- Olurinde A. OniKansas City VA Medical Center
- Maya S. SafarovaUniversity of Kansas Medical Center
Abstract
Objective
The aim of the study was to examine the effects of the vitamin D (Vit-D) treatment and nontreatment on Vit-D-deficient patients without a prior history of myocardial infarction (MI).
Materials and methods
This was a retrospective, observational, nested case-control study of patients (N = 20 025) with low 25-hydroxyvitamin D ([25-OH]D) levels (<20 ng/mL) who received care at the Veterans Health Administration from 1999 to 2018. Patients were divided into 3 groups: Group A (untreated, levels ≤20 ng/mL), Group B (treated, levels 21-29 ng/mL), and Group C (treated, levels ≥30 ng/mL). The risk of MI and all-cause mortality were compared utilizing propensity score-weighted Cox proportional hazard models.
Results
Among the cohort of 20 025 patients, the risk of MI was significantly lower in Group C than in Group B (hazard ratio [HR] 0.65, 95% CI 0.49-0.85, P = .002) and Group A (HR 0.73, 95% CI 0.55-0.96), P = .02). There was no difference in the risk of MI between Group B and Group A (HR 1.14, 95% CI 0.91-1.42, P = 0.24). Compared with Group A, both Group B (HR 0.59, 95% CI 0.54-0.63, P P P = .78).
Conclusions
In patients with Vit-D deficiency and no prior history of MI, treatment to the (25-OH)D level of >20 ng/mL and >30 ng/mL was associated with a significantly lower risk of all-cause mortality. The lower risk of MI was observed only in individuals maintaining (25-OH)D levels ≥30 ng/mL.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-ND).
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