Exercise hyperthermia induces greater changes in gastrointestinal permeability than equivalent passive hyperthermia
Walter E, W Watt P, Gibson OR, Wilmott AGB, Mitchell D, Moreton R, Maxwell NS
Physiological reports · 20 citations
How it was studied
- Design
- Controlled clinical trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
Based on full-text disclosure statement.
Publication
- Published
- 2021-08-01 · Physiol Rep · vol. 9 · issue 16 · p. e14945
- Publisher
- Wiley
- Cited
- 24 citations · more than 83% of similar papers · 1.6× the field average
- References
- 35 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Thermoregulation and physiological responses · Exercise and Physiological Responses · Climate Change and Health Impacts
- Keywords
- Hyperthermia, Medicine, Thermoregulation, Internal medicine, Heat illness, Rating of perceived exertion, Heart rate, Endocrinology, Chemistry, Cardiology, Blood pressure
- MeSH
- humans, body temperature, exercise, oxygen consumption, adult, male, gastrointestinal absorption, hyperthermia
7 authors
From GB
- Edward James WalterRoyal Surrey County Hospital; University of Brighton
- Peter WattUniversity of Brighton
- Oliver R. Gibson · correspondingBrunel University of London
- Ashley G. B. WilmottAnglia Ruskin University; University of Brighton
- Dominic MitchellUniversity of Brighton
- Robert MoretonUniversity of Brighton
Abstract
Hyperthermia and exertional heat illness increase gastrointestinal (GI) permeability, although whether the latter is only via hyperthermia is unclear. The aim of this pilot study was to determine whether different changes in GI permeability, characterized by an increased plasma lactulose:rhamnose concentration ratio ([L:R]), occurred in exercise hyperthermia in comparison to equivalent passive hyperthermia. Six healthy adult male participants (age 25 ± 5 years, mass 77.0 ± 6.7 kg, height 181 ± 6 cm, peak oxygen uptake [ V·O2peak ] 48 ± 8 ml.kg-1 .min-1 ) underwent exercise under hot conditions (Ex-Heat) and passive heating during hot water immersion (HWI). Heart rate (HR), rectal temperature (TCORE ), rating of perceived exertion (RPE), and whole-body sweat loss (WBSL) were recorded throughout the trials. The L:R ratio, peak HR, change in HR, and change in RPE were higher in Ex-Heat than HWI, despite no differences in trial duration, peak core temperature or WBSL. L:R was strongly correlated (p CORE responses to HWI, indicates that increased cardiovascular strain occurred during exercise, and exacerbates hyperthermia-induced GI permeability at the same absolute temperature.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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