Effects of n-3 Polyunsaturated Fatty Acid-Enriched Hen Egg Consumption on the Inflammatory Biomarkers and Microvascular Function in Patients with Acute and Chronic Coronary Syndrome-A Randomized Study
Ćurić ŽB, Masle AM, Kibel A, Selthofer-Relatić K, Stupin A, Mihaljević Z, Jukić I, Stupin M, Matić A, Kozina N, Šušnjara P, Juranić B, Kolobarić N, Šerić V, Drenjančević I
Biology · 12 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Food provided by researchers
Who paid for it
- Funding
- Independent funding
- Government
- European Structural and Investment Funds grant for the Croatian National Scientific Center of Excellence for Personalized Health Care, University of Josip Juraj Strossmayer Osijek
Based on 1 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2021-08-14 · Biology (Basel) · vol. 10 · issue 8 · p. 774
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 15 citations · more than 80% of similar papers · 1.2× the field average
- References
- 52 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Cardiovascular Disease and Adiposity · Fatty Acid Research and Health · Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- Polyunsaturated fatty acid, Coronary artery disease, Internal medicine, Biology, Endocrinology, Fatty acid, Gastroenterology, C-reactive protein, Inflammation, Biochemistry, Medicine
15 authors
From HR
- Željka Breškić ĆurićPolytechnic of Međimurje in Čakovec; University of Osijek
- Ana Marija MasleUniversity of Osijek
- Aleksandar KibelUniversity of Osijek
- Kristina Selthofer-RelatićUniversity of Osijek
- Ana Stupin · correspondingUniversity of Osijek
- Zrinka MihaljevićUniversity of Osijek
Abstract
This study aimed to test the effect of n-3 polyunsaturated fatty acid (PUFA)-enriched hen egg consumption on serum lipid and free fatty acid profiles, inflammatory and oxidative stress biomarkers, and microvascular reactivity in patients with coronary artery disease (CAD). Forty CAD patients participated in this study. Of those, 20 patients had acute CAD (Ac-CAD), and 20 patients had chronic CAD (Ch-CAD). The control group (N = 20) consumed three regular hen eggs/daily (249 mg n-3 PUFAs/day), and the n-3 PUFAs group (N = 20) consumed three n-3 PUFA-enriched hen eggs/daily (1053 g n-3 PUFAs/day) for 3 weeks. Serum n-3 PUFA concentration significantly increased (in all CAD patients), while LDL cholesterol and IL-6 (in Ac-CAD patients), and hsCRP and IL-1a (in all CAD patients) significantly decreased in the n-3 PUFAs group. Glutathione peroxidase (GPx) activity significantly decreased, and forearm skin microvascular reactivity in response to vascular occlusion (postocclusive reactive hyperemia (PORH)) remained unchanged in both the n-3 PUFAs and control groups in total CAD, Ac-CAD, and Ch-CAD patients. Potentially, n-3 PUFA-enriched hen eggs can change the free fatty acid profile to a more favorable lower n6/n3 ratio, and to exhibit mild anti-inflammatory effects but not to affect microvascular reactivity in CAD patients.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.