Chronic Dialysis Patients Are Depleted of Creatine: Review and Rationale for Intradialytic Creatine Supplementation
van der Veen Y, Post A, Kremer D, Koops CA, Marsman E, Appeldoorn TYJ, Touw DJ, Westerhuis R, Heiner-Fokkema MR, Franssen CFM, Wallimann T, Bakker SJL
Nutrients · 13 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- University or hospital
- Universitair Medisch Centrum Groningen
- Authors
- At least one author declares a financial tie to industry
Based on 1 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2021-08-06 · Nutrients · vol. 13 · issue 8 · p. 2709
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 20 citations · more than 75% of similar papers · 1.2× the field average
- References
- 86 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Muscle metabolism and nutrition · Dialysis and Renal Disease Management · Nutrition and Health in Aging
- Keywords
- Creatine, Medicine, Hemodialysis, Kidney disease, Dialysis, Internal medicine, Creatinine, Creatine Monohydrate, Placebo, Intensive care medicine, Urinary system, Endocrinology, Pathology
- MeSH
- humans, creatine, treatment outcome, renal dialysis, pilot projects, double-blind method, health status, time factors, dietary supplements, netherlands, renal insufficiency, chronic, randomized controlled trials as topic
12 authors
From NL, CH
- Yvonne van der Veen · correspondingUniversity Medical Center Groningen; University of Groningen
- Adrian Post · correspondingUniversity Medical Center Groningen; University of Groningen
- Daan KremerUniversity Medical Center Groningen; University of Groningen
- Christa A. KoopsUniversity Medical Center Groningen; University of Groningen
- E. Madelief MarsmanDialyse Centrum Groningen
- Theo Y. Jerôme AppeldoornUniversity Medical Center Groningen; University of Groningen
Abstract
There is great need for the identification of new, potentially modifiable risk factors for the poor health-related quality of life (HRQoL) and of the excess risk of mortality in dialysis-dependent chronic kidney disease patients. Creatine is an essential contributor to cellular energy homeostasis, yet, on a daily basis, 1.6-1.7% of the total creatine pool is non-enzymatically degraded to creatinine and subsequently lost via urinary excretion, thereby necessitating a continuous supply of new creatine in order to remain in steady-state. Because of an insufficient ability to synthesize creatine, unopposed losses to the dialysis fluid, and insufficient intake due to dietary recommendations that are increasingly steered towards more plant-based diets, hemodialysis patients are prone to creatine deficiency, and may benefit from creatine supplementation. To avoid problems with compliance and fluid balance, and, furthermore, to prevent intradialytic losses of creatine to the dialysate, we aim to investigate the potential of intradialytic creatine supplementation in improving outcomes. Given the known physiological effects of creatine, intradialytic creatine supplementation may help to maintain creatine homeostasis among dialysis-dependent chronic kidney disease patients, and consequently improve muscle status, nutritional status, neurocognitive status, HRQoL. Additionally, we describe the rationale and design for a block-randomized, double-blind, placebo-controlled pilot study. The aim of the pilot study is to explore the creatine uptake in the circulation and tissues following different creatine supplementation dosages.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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