Magnesium intake and vascular structure and function: the Hoorn Study
Vermeulen EA, de Jong HBT, Blomjous AGA, Eelderink C, Hoekstra T, Elders PJM, de Borst MH, Vervloet MG, van Ballegooijen AJ, Beulens JW
European journal of nutrition · 6 citations
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- ZonMw
- Nonprofit
- Nierstichting
- Nonprofit
- Diabetes Fonds
- Government
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Government
- ZonMW NWO-Vidi grant
- Nonprofit
- Dutch Diabetes Research Foundation
- Government
- Health Holland
- Grants
- Diabetes Fonds (2005.00.010); Nederlandse Organisatie voor Wetenschappelijk Onderzoek (91 71 8304); Nierstichting (16TKI02); ZonMw (91718304); Diabetes Fonds (2003.01.004); Diabetes Fonds (2005.00.010, 2003.01.004)
Based on 7 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2021-09-07 · Eur J Nutr · vol. 61 · issue 2 · pp. 653–664
- Publisher
- Springer Science+Business Media
- Cited
- 7 citations · more than 62% of similar papers · 0.6× the field average
- References
- 65 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Magnesium in Health and Disease · Cardiovascular Health and Disease Prevention · Parathyroid Disorders and Treatments
- Keywords
- Medicine, Prospective cohort study, Pulse wave velocity, Cohort, Internal medicine, Cohort study, Confidence interval, Logistic regression, Population, Cardiology, Blood pressure, Environmental health
- MeSH
- humans, magnesium, risk factors, prospective studies, cross-sectional studies, carotid intima-media thickness, vascular stiffness, pulse wave analysis
10 authors
From NL
- Emma A. VermeulenAmsterdam UMC Location Vrije Universiteit Amsterdam
- Hanne B. T. de JongWageningen University & Research
- Alexander G. A. BlomjousAmsterdam UMC Location Vrije Universiteit Amsterdam
- Coby EelderinkUniversity Medical Center Groningen; University of Groningen
- Tiny HoekstraAmsterdam UMC Location Vrije Universiteit Amsterdam
- Petra J. M. EldersAmsterdam Public Health; Amsterdam UMC Location Vrije Universiteit Amsterdam
Abstract
Purpose
Circulating and dietary magnesium have been shown to be inversely associated with the prevalence of cardiovascular disease (CVD) and mortality in both high and low-risk populations. We aimed to examine the association between dietary magnesium intake and several measures of vascular structure and function in a prospective cohort.
Methods
We included 789 participants who participated in the vascular screening sub-cohort of the Hoorn Study, a population-based, prospective cohort study. Baseline dietary magnesium intake was estimated with a validated food frequency questionnaire and categorised in energy-adjusted magnesium intake tertiles. Several measurements of vascular structure and function were performed at baseline and most measurements were repeated after 8 years of follow-up (n = 432). Multivariable linear and logistic regression was performed to study the cross-sectional and longitudinal associations of magnesium intake and intima-media thickness (IMT), augmentation index (Aix), pulse wave velocity (PWV), flow-mediated dilatation (FMD), and peripheral arterial disease (PAD).
Results
Mean absolute magnesium intake was 328 ± 83 mg/day and prior CVD and DM2 was present in 55 and 41% of the participants, respectively. Multivariable regression analyses did not demonstrate associations between magnesium intake and any of the vascular outcomes. Participants in the highest compared to the lowest magnesium intake tertile demonstrated in fully adjusted cross-sectional analyses a PWV of -0.21 m/s (95% confidence interval -1.95, 1.52), a FMD of -0.03% (-0.89, 0.83) and in longitudinal analyses an IMT of 0.01 mm (-0.03, 0.06), an Aix of 0.70% (-1.69, 3.07) and an odds ratio of 0.84 (0.23, 3.11) for PAD CONCLUSION: We did not find associations between dietary magnesium intake and multiple markers of vascular structure and function, in either cross-sectional or longitudinal analyses.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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