Funded in part by Alpro Foundation
Longer-term soy nut consumption improves cerebral blood flow and psychomotor speed: results of a randomized, controlled crossover trial in older men and women
Kleinloog JPD, Tischmann L, Mensink RP, Adam TC, Joris PJ
The American journal of clinical nutrition · 25 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Food provided by researchers
Who paid for it
- Funding
- Industry funded
- Government
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Company
- Alpro Foundation
- Government
- Dutch Research Council (NWO)
- Grants
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek (ALWTF.2016.012); Nederlandse Organisatie voor Wetenschappelijk Onderzoek (ASPASIA 015.010.034); Nederlandse Organisatie voor Wetenschappelijk Onderzoek (015.010.034)
Based on 3 listed funder(s).
Publication
- Published
- 2021-08-12 · Am J Clin Nutr · vol. 114 · issue 6 · pp. 2097–2106
- Publisher
- Elsevier BV
- Cited
- 30 citations · more than 89% of similar papers · 2.4× the field average
- References
- 53 works
- Access
- Open access (hybrid journal) · CC-BY-NC
- Research areas
- Phytoestrogen effects and research · Nutritional Studies and Diet · Nuts composition and effects
- Keywords
- Nut, Crossover study, Randomized controlled trial, Medicine, Consumption (sociology), Term (time), Psychomotor learning, Internal medicine, Engineering, Cognition
- MeSH
- humans, nuts, isoflavones, genistein, cross-over studies, cerebrovascular circulation, soy foods, aged, middle aged, female, male
5 authors
From NL
- Jordi P. D. KleinloogMaastricht University
- Lea TischmannMaastricht University
- Ronald P. MensinkMaastricht University
- Tanja C. AdamMaastricht University
- Peter J. Joris · correspondingMaastricht University
Abstract
Background
Effects of soy foods on cerebral blood flow (CBF)-a marker of cerebrovascular function-may contribute to the beneficial effects of plant-based diets on cognitive performance.
Objectives
We aimed to investigate longer-term effects of soy nut consumption on CBF in older adults. Changes in 3 different domains of cognitive performance were also studied.
Methods
Twenty-three healthy participants (age: 60-70 y; BMI: 20-30 kg/m2) participated in a randomized, controlled, single-blinded crossover trial with an intervention (67 g/d of soy nuts providing ∼25.5 g protein and 174 mg isoflavones) and control period (no nuts) of 16 wk, separated by an 8-wk washout period. Adults followed the Dutch food-based dietary guidelines. At the end of each period, CBF was assessed with arterial spin labeling MRI. Psychomotor speed, executive function, and memory were assessed using the Cambridge Neuropsychological Test Automated Battery (CANTAB).
Results
No serious adverse events were reported, and soy nut intake was well tolerated. Body weights remained stable during the study. Serum isoflavone concentrations increased (daidzein mean difference ± SD: 128 ± 113 ng/mL, P < 0.001; genistein: 454 ± 256 ng/mL, P < 0.001), indicating excellent compliance. Regional CBF increased in 4 brain clusters located in the left occipital and temporal lobes (mean ± SD increase: 11.1 ± 12.4 mL · 100 g-1 · min-1, volume: 11,296 mm3, P < 0.001), bilateral occipital lobe (12.1 ± 15.0 mL · 100 g-1 · min-1, volume: 2632 mm3, P = 0.002), right occipital and parietal lobes (12.7 ± 14.3 mL · 100 g-1 · min-1, volume: 2280 mm3, P = 0.005), and left frontal lobe (12.4 ± 14.5 mL · 100 g-1 · min-1, volume: 2120 mm3, P = 0.009) which is part of the ventral network. These 4 regions are involved in psychomotor speed performance, which improved as the movement time reduced by (mean ± SD) 20 ± 37 ms (P = 0.005). Executive function and memory did not change.
Conclusions
Longer-term soy nut consumption may improve cerebrovascular function of older adults, because regional CBF increased. Effects may underlie observed improvements in psychomotor speed.This trial was registered at clinicaltrials.gov as NCT03627637.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC).
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