Hypohydration produced by high-intensity intermittent running increases biomarkers of renal injury in males
Juett LA, Midwood KL, Funnell MP, James LJ, Mears SA
European journal of applied physiology · 8 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2021-09-15 · Eur J Appl Physiol · vol. 121 · issue 12 · pp. 3485–3497
- Publisher
- Springer Science+Business Media
- Cited
- 12 citations · more than 75% of similar papers · 1.0× the field average
- References
- 70 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Thermoregulation and physiological responses · Exercise and Physiological Responses · Muscle metabolism and nutrition
- Keywords
- Urine osmolality, Urine specific gravity, Medicine, Urine, Plasma osmolality, Body water, Urinary system, Internal medicine, Chemistry, Urology, Endocrinology, Body weight
- MeSH
- humans, dehydration, body mass index, cross-over studies, running, osmolar concentration, adult, male, hot temperature, acute kidney injury, biomarkers
5 authors
From GB
- Loris A. JuettLoughborough University
- Katharine L. MidwoodLoughborough University
- Mark P. FunnellLoughborough University
- Lewis John JamesLoughborough University
- Stephen A. Mears · correspondingLoughborough University
Abstract
Purpose
Whilst there is evidence to suggest that hypohydration caused by physical work in the heat increases renal injury, whether this is the case during exercise in temperate conditions remains unknown. This study investigated the effect of manipulating hydration status during high-intensity intermittent running on biomarkers of renal injury.
Methods
After familiarisation, 14 males (age: 33 ± 7 years; V̇O2peak: 57.1 ± 8.6 ml/kg/min; mean ± SD) completed 2 trials in a randomised cross-over design, each involving 6, 15 min blocks of shuttle running (modified Loughborough Intermittent Shuttle Test protocol) in temperate conditions (22.3 ± 1.0 °C; 47.9 ± 12.9% relative humidity). During exercise, subjects consumed either a volume of water equal to 90% of sweat losses (EU) or 75 mL water (HYP). Body mass, blood and urine samples were taken pre-exercise (baseline/pre), 30 min post-exercise (post) and 24 h post-baseline (24 h).
Results
Post-exercise, body mass loss, serum osmolality and urine osmolality were greater in HYP than EU (P ≤ 0.024). Osmolality-corrected urinary kidney injury molecule-1 (uKIM-1) concentrations were increased post-exercise (P ≤ 0.048), with greater concentrations in HYP than EU (HYP: 2.76 [1.72-4.65] ng/mOsm; EU: 1.94 [1.1-2.54] ng/mOsm; P = 0.003; median [interquartile range]). Osmolality-corrected urinary neutrophil gelatinase-associated lipocalin (uNGAL) concentrations were increased post-exercise (P < 0.001), but there was no trial by time interaction effect (P = 0.073).
Conclusion
These results suggest that hypohydration produced by high-intensity intermittent running increases renal injury, compared to when euhydration is maintained, and that the site of this increased renal injury is at the proximal tubules.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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