Effect of an ashwagandha (Withania Somnifera) root extract on climacteric symptoms in women during perimenopause: A randomized, double-blind, placebo-controlled study
Gopal S, Ajgaonkar A, Kanchi P, Kaundinya A, Thakare V, Chauhan S, Langade D
The journal of obstetrics and gynaecology research · 36 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2021-09-22 · J Obstet Gynaecol Res · vol. 47 · issue 12 · pp. 4414–4425
- Publisher
- Wiley
- Cited
- 52 citations · more than 93% of similar papers · 4.1× the field average
- Impact
- Top 10% most cited in its field
- References
- 39 works
- Access
- Paywalled
- Research areas
- Phytochemicals and Medicinal Plants · Menopause: Health Impacts and Treatments · Estrogen and related hormone effects
- Keywords
- Climacteric, Medicine, Placebo, Menopause, Withania somnifera, Testosterone (patch), Tolerability, Hormone, Internal medicine, Luteinizing hormone, Randomized controlled trial, Physiology, Black cohosh, Endocrinology, Adverse effect
- MeSH
- humans, withania, hot flashes, plant extracts, double-blind method, perimenopause, quality of life, female
7 authors
From IN
- Sriram GopalD.Y. Patil University
- Ashutosh AjgaonkarBhaktivedanta Hospital & Research Institute
- Padmaja KanchiTerna Dental College and Hospital
- Aditi KaundinyaD.Y. Patil University
- Vaishali Thakare · correspondingD.Y. Patil University
- Sanjaya ChauhanNarayana Health
Abstract
Background
Perimenopause is the period during which many physiological changes mark the transition into the final menstrual period of a woman and these changes are associated with climacteric symptoms.
Objectives
This study aimed to assess the efficacy and tolerability of an Ashwagandha root extract on the climacteric symptoms, quality of life (QoL), and hormonal parameters in perimenopausal women.
Materials and methods
In this 8-week, randomized, double-blind, placebo-controlled study, 100 women with climacteric symptoms were randomly allocated to take either a placebo or 300 mg of an Ashwagandha root extract twice daily. Outcomes were measured using the menopause rating scale (MRS), menopause-specific QoL (MENQoL), hot flash score, and hormonal changes in estradiol, follicle-stimulating hormone (FSH), luteinizing hormone (LH), and testosterone.
Results
Among 100 participants enrolled, 91 participants completed the study. In comparison with the placebo, ashwagandha supplementation was associated with a statistically significant reduction in total MRS score (p < 0.0001), reflected by significant reductions in the psychological (p = 0.0003), somato-vegetative (p = 0.0152), and urogenital (p < 0.0001) domains. Ashwagandha intake demonstrated a statistically significant reduction in total MENQoL scores (p < 0.0001) and was also associated with a statistically significant increase in serum estradiol (p < 0.0001) and a significant reduction in serum FSH (p < 0.0001) and serum LH (p < 0.05) compared with the placebo. There was no significant between the group differences in the serum testosterone level.
Conclusion
These findings suggest that ashwagandha root extract can be a safe and effective option to relieve mild to moderate climacteric symptoms during perimenopause in women.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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