Missing puzzle pieces of time-restricted-eating (TRE) as a long-term weight-loss strategy in overweight and obese people? A systematic review and meta-analysis of randomized controlled trials
Chen JH, Lu LW, Ge Q, Feng D, Yu J, Liu B, Zhang R, Zhang X, Ouyang C, Chen F
Critical reviews in food science and nutrition · 35 citations
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- National Natural Science Foundation of China
- Government
- Shenzhen Science and Technology Program
- Government
- Guangdong Province Zhujiang Talent Program
- Grants
- National Natural Science Foundation of China (31601472)
Based on 3 listed funder(s).
Publication
- Published
- 2021-09-23 · Crit Rev Food Sci Nutr · vol. 63 · issue 15 · pp. 2331–2347
- Publisher
- Taylor & Francis
- Cited
- 46 citations · more than 81% of similar papers · 1.3× the field average
- References
- 63 works
- Access
- Paywalled
- Research areas
- Dietary Effects on Health · Diet and metabolism studies · Circadian rhythm and melatonin
- Keywords
- Overweight, Meta-analysis, Weight loss, Term (time), Randomized controlled trial, Medicine, Obesity, Gerontology, Psychology, Pediatrics, Internal medicine
- MeSH
- humans, obesity, weight loss, overweight, cholesterol, ldl, randomized controlled trials as topic
10 authors
From CN, NZ
- Jie‐Hua ChenShenzhen University
- Louise Weiwei LuUniversity of Auckland
- Qian GeJinan University; Southern University of Science and Technology
- Dana FengSun Yat-sen University; Sun Yat-sen Memorial Hospital
- Jianfeng YuShenzhen University
- Bin LiuShenzhen University
Abstract
The efficacy of using time restricted eating (TRE) for weight management and to mitigate metabolic disorders in overweight and obese people remains debatable. This meta-analysis quantified the impact of TRE on weight loss and metabolic health in overweight and obese people. The pooled results were subjected to a random-effects modeling using Hartung-Knapp-Sidik-Jonkman (HKSJ) method. Additionally, subgroup analysis was conducted based on study types, randomized controlled trials (RCTs) vs. non-randomized studies of interventions (NRSIs). Pooled results showed that subjects on TRE regimen (> 4 weeks) achieved a significant weight loss in comparison with unrestricted time regimen (weighted mean difference: -2.32%; 95% CI: -3.50, -1.14%; p < 0.01); however, weight loss was mainly attributed to the loss of lean mass rather than fat mass. The magnitude of weight loss was inversely correlated with daily fasting duration in RCTs. TRE significantly decreased the diastolic blood pressure and fasting insulin. An increase of low-density lipoprotein cholesterol (LDL-C) was observed in the TRE group. Favorable effect of TRE was observed on glucose metabolism but not on lipid profiles independent of weight loss. Hence TRE shall be administered with caution to overweight and obese people who have comorbidities such as dyslipidemia and sarcopenia.Supplemental data for this article is available online at https://doi.org/10.1080/10408398.2021.1974335.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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