Association of Nut Consumption with Risk of Stroke and Cardiovascular Disease: The Million Veteran Program
Ivey KL, Nguyen XT, Quaden RM, Ho YL, Cho K, Gaziano JM, Djoussé L
Nutrients · 8 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Independent funding
- Government
- U.S. Department of Veterans Affairs
- Government
- Health Services Research and Development
- Government
- BLRD VA
- Grants
- U.S. Department of Veterans Affairs (I01 BX003340); Health Services Research and Development (13-457); U.S. Department of Veterans Affairs (HSR RES 13-457); U.S. Department of Veterans Affairs (MVP001 and MVP#000 and I01 BX00334001.); U.S. Department of Veterans Affairs (I01-BX004821); U.S. Department of Veterans Affairs (MVP001); U.S. Department of Veterans Affairs (VA HSR RES 13‐457); U.S. Department of Veterans Affairs (98‐004); U.S. Department of Veterans Affairs (SDR 02-237); U.S. Department of Veterans Affairs (RES 13-457); Health Services Research and Development (VA HSR RES 13-457); Health Services Research and Development (SDR 02‐237); Health Services Research and Development (MVP001)
Based on 3 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2021-08-30 · Nutrients · vol. 13 · issue 9 · p. 3031
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 12 citations · more than 66% of similar papers · 0.7× the field average
- References
- 31 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Nuts composition and effects · Antioxidant Activity and Oxidative Stress · Nutritional Studies and Diet
- Keywords
- Medicine, Stroke (engine), Hazard ratio, Coronary artery disease, Proportional hazards model, Nut, Veterans Affairs, Disease, Incidence (geometry), Internal medicine, National Death Index, Emergency medicine, Confidence interval
- MeSH
- humans, nuts, cardiovascular diseases, diet, incidence, prospective studies, adult, aged, aged, 80 and over, middle aged, veterans, united states, female, male, stroke, young adult, surveys and questionnaires
7 authors
From US, AU
- Kerry Lee Ivey · correspondingHarvard University; South Australian Health and Medical Research Institute
- Xuan‐Mai T. NguyenBrigham and Women's Hospital; Harvard University
- Rachel M. Quaden
- Yuk-Lam Anne Ho
- Kelly ChoBrigham and Women's Hospital; Harvard University
- J. Michael GazianoBrigham and Women's Hospital; Harvard University
Abstract
Cardiovascular disease (CVD), including stroke and coronary artery disease (CAD), is the major cause of mortality for Americans. Nuts have been shown to improve a variety of cardiovascular disease risk factors. This study aimed to test the hypothesis that nut consumption is inversely associated with risk of incidence of stroke, CAD, and CVD mortality in the prospective Million Veterans Program (MVP). A total of 179,827 MVP participants enrolled between 2011 and 2018 were free of CVD prior to assessment of nut consumption via the food frequency questionnaire. Incident stroke and CVD events were ascertained from the Veterans Affairs electronic medical health records and the National Death Index. We used the Cox regression model to compute multivariable adjusted hazard ratios. Over the 3.5-year median follow-up, 3362 new cases of ischemic stroke were identified. When compared with participants who rarely or never consumed nuts, those consuming nuts ≥ 5 times per week were 19% less likely to experience a stroke (95% CI: 8% to 28%); 22% less likely to suffer from CAD (95% CI: 16% to 28%); and 24% less likely to die from CVD (95% CI: 7% to 37%). Consumption of peanut butter was not associated with risk of stroke. Increased dietary intake of nuts, but not peanut butter, was associated with a lower risk of stroke, CAD, and CVD death.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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