Randomized controlled trial2021

Timing of creatine supplementation does not influence gains in unilateral muscle hypertrophy or strength from resistance training in young adults: a within-subject design

Forbes SC, Krentz JR, Candow DG

The Journal of sports medicine and physical fitness · 6 citations

Review labels

Funding not disclosed

Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.

How it was studied

Design
Randomized controlled trial (indexed by PubMed)
Studied in
People
Main outcome
Health markers and function

Who paid for it

Funding
Funding not disclosed

Publication

Published
2021-10-01 · J Sports Med Phys Fitness · vol. 61 · issue 9 · pp. 1219–1225
Publisher
Edizioni Minerva Medica
Cited
11 citations · more than 69% of similar papers · 0.9× the field average
References
25 works
Access
Paywalled
Research areas
Muscle metabolism and nutrition · Cardiovascular and exercise physiology · Sports Performance and Training
Keywords
Muscle hypertrophy, Creatine, Medicine, Placebo, Creatine Monohydrate, Resistance training, Strength training, Elbow, Physical strength, Physical therapy, Muscle mass, Internal medicine, Anatomy
MeSH
muscle, skeletal, humans, hypertrophy, creatine, dietary supplements, adolescent, adult, female, male, muscle strength, resistance training, young adult

3 authors

From CA

  • Scott C. Forbes · correspondingBrandon University
  • Joel R. KrentzBrandon University
  • Darren Glenn CandowUniversity of Regina

Abstract

Background

Creatine supplementation, in close proximity to resistance training sessions, may be an important strategy to augment muscle accretion and strength. The purpose of this study was to examine the effects of creatine supplementation immediately before compared to immediately after unilateral resistance training on hypertrophy and strength.

Methods

Using a counter-balanced, double-blind, repeated measures within-subject design, ten recreationally active participants (7 males; 3 females; age: 23±5 years; height: 174±9 cm; body mass: 73.5±9.7 kg) were randomized to supplement with creatine monohydrate (0.1 g/kg of body mass) immediately before and placebo immediately after training one side of the body and placebo immediately before and creatine immediately after training the other side of the body on alternate days. Resistance training consisted of elbow flexion and knee extension (3-6 sets at 80% 1-repetition maximum [1-RM]) for 8 weeks. Prior to and following training, muscle thickness (elbow flexors and leg extensors; ultrasonography) and strength (1-RM for the elbow flexors and knee extensors) was assessed.

Results

There was a significant increase over time for muscle thickness, strength, and relative strength (P<0.01), with no differences between creatine ingestion strategies. Total training volume performed was similar between conditions (P=0.56).

Conclusions

Creatine supplementation, immediately before or immediately after unilateral resistance training, produces similar gains in muscle hypertrophy and strength in young adults.

Abstract via Europe PMC. Copyright remains with the authors or publisher.

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