Time-restricted feeding improves blood glucose and insulin sensitivity in overweight patients with type 2 diabetes: a randomised controlled trial
Che T, Yan C, Tian D, Zhang X, Liu X, Wu Z
Nutrition & metabolism · 149 citations
How it was studied
- Design
- Randomized controlled trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- Innovative Research Group Project of the National Natural Science Foundation of China
- Government
- National Natural Science Foundation of China
- Government
- Natural Science Foundation of Tianjin City
- Government
- Natural Science Foundation of Tianjin Municipal Science and Technology Commission
- Government
- Natural Science Foundation of Tianjin-Science and Technology Correspondent Project
- Grants
- Natural Science Foundation of Tianjin City (19JCZDJC36900); Natural Science Foundation of Tianjin Municipal Science and Technology Commission (RC20165); National Natural Science Foundation of China (81671835); National Natural Science Foundation of China (ZC20143); Natural Science Foundation of Tianjin Municipal Science and Technology Commission (19JCZDJC36900); Innovative Research Group Project of the National Natural Science Foundation of China (81671835); Natural Science Foundation of Tianjin-Science and Technology Correspondent Project (ZC20143)
Based on 5 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2021-10-07 · Nutr Metab (Lond) · vol. 18 · issue 1 · p. 88
- Publisher
- BioMed Central
- Cited
- 211 citations · more than 99% of similar papers · 13.1× the field average
- Impact
- Top 10% most cited in its field
- References
- 48 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Dietary Effects on Health · Enhanced Recovery After Surgery · Genetics, Aging, and Longevity in Model Organisms
- Keywords
- Overweight, Medicine, Internal medicine, Type 2 diabetes, Clinical nutrition, Diabetes mellitus, Insulin resistance, Insulin, Endocrinology, Obesity, Randomized controlled trial, Gastroenterology
6 authors
From CN
- Tingting CheTianjin Medical University
- Yan ChengTianjin Medical University
- Ding‐Yuan TianTianjin Medical University
- Xin ZhangTianjin Medical University
- Xuejun Liu · correspondingTianjin Medical University
- Zhongming Wu · correspondingSecond Hospital of Tianjin Medical University; Tianjin Medical University
Abstract
Background
Time-restricted feeding is an emerging dietary intervention that is becoming increasingly popular. There are, however, no randomised clinical trials of time-restricted feeding in overweight patients with type 2 diabetes. Here, we explored the effects of time-restricted feeding on glycaemic regulation and weight changes in overweight patients with type 2 diabetes over 12 weeks.
Methods
Overweight adults with type 2 diabetes (n = 120) were randomised 1:1 to two diet groups: time-restricted feeding (n = 60) or control (n = 60). Sixty patients participated in a 10-h restricted feeding treatment program (ad libitum feeding from 8:00 to 18:00 h; fasting between 18:00 and 8:00 h) for 12 weeks.
Results
Haemoglobin A1c and body weight decreased in the time-restricted feeding group (- 1.54% ± 0.19 and - 2.98 ± 0.43 kg, respectively) relative to the control group over 12 weeks (p < 0.001). Homeostatic model assessment of β-cell function and insulin resistance changed in the time-restricted feeding group (0.73 ± 0.21, p = 0.005; - 0.51 ± 0.08, p = 0.02, respectively) compared with the control group. The medication effect score, SF-12 score, and the levels of triglycerides, total cholesterol and low-density lipoprotein cholesterol were improved in the time-restricted feeding group (- 0.66 ± 0.17, p = 0.006; 5.92 ± 1.38, p < 0.001; - 0.23 ± 0.08 mmol/L, p = 0.03; - 0.32 ± 0.07 mmol/L, p = 0.01; - 0.42 ± 0.13 mmol/L, p = 0.02, respectively) relative to the control group. High-density lipoprotein cholesterol was not significantly different between the two groups.
Conclusion
These results suggest that 10-h restricted feeding improves blood glucose and insulin sensitivity, results in weight loss, reduces the necessary dosage of hypoglycaemic drugs and enhances quality of life. It can also offer cardiovascular benefits by reducing atherosclerotic lipid levels.
Trial registration
This study was registered with the Chinese Clinical Trial Registry (ChiCTR-IPR-15006371).
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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