Tormenting thoughts: The posterior cingulate sulcus of the default mode network regulates valence of thoughts and activity in the brain's pain network during music listening
Koelsch S, Andrews-Hanna JR, Skouras S
Human brain mapping · 21 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- In vitro/mechanistic study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Mechanisms only
Who paid for it
- Funding
- Independent funding
Based on full-text disclosure statement.
Publication
- Published
- 2021-10-15 · Hum Brain Mapp · vol. 43 · issue 2 · pp. 773–786
- Publisher
- Wiley
- Cited
- 30 citations · more than 81% of similar papers · 1.5× the field average
- References
- 63 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Mind wandering and attention · Functional Brain Connectivity Studies · Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- Default mode network, Posterior cingulate, Valence (chemistry), Psychology, Mind-wandering, Functional magnetic resonance imaging, Sulcus, Neuroscience, Orbitofrontal cortex, Ventromedial prefrontal cortex, Anterior cingulate cortex, Cingulate cortex, Cognitive psychology, Prefrontal cortex, Cognition, Chemistry, Central nervous system
- MeSH
- gyrus cinguli, prefrontal cortex, nerve net, humans, pain, magnetic resonance imaging, emotions, auditory perception, thinking, music, adult, female, male, young adult, connectome, default mode network
3 authors
From NO, US
- Stefan Koelsch · correspondingUniversity of Bergen
- Jessica R. Andrews‐HannaUniversity of Arizona; Arizona Science Center; Cognitive Engineering Research Institute
- Stavros SkourasUniversity of Bergen
Abstract
Many individuals spend a significant amount of their time "mind-wandering". Mind-wandering often includes spontaneous, nonintentional thought, and a neural correlate of this kind of thought is the default mode network (DMN). Thoughts during mind-wandering can have positive or negative valence, but only little is known about the neural correlates of positive or negative thoughts. We used resting-state functional magnetic resonance imaging (fMRI) and music to evoke mind-wandering in n = 33 participants, with positive-sounding music eliciting thoughts with more positive valence and negative-sounding music eliciting thoughts with more negative valence. Applying purely data-driven analysis methods, we show that medial orbitofrontal cortex (mOFC, part of the ventromedial prefrontal cortex) and the posterior cingulate sulcus (likely area 23c of the posterior cingulate cortex), two sub-regions of the DMN, modulate the valence of thought-contents during mind-wandering. In addition, across two independent experiments, we observed that the posterior cingulate sulcus, a region involved in pain, shows valence-specific functional connectivity with core regions of the brain's putative pain network. Our results suggest that two DMN regions (mOFC and posterior cingulate sulcus) support the formation of negative spontaneous, nonintentional thoughts, and that the interplay between these structures with regions of the putative pain network forms a neural mechanism by which thoughts can become painful.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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