Nut consumption in association with overall mortality and recurrence/disease-specific mortality among long-term breast cancer survivors
Wang C, Gu K, Wang F, Cai H, Zheng W, Bao P, Shu XO
International journal of cancer · 6 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- Government
- U.S. Department of Defense
- Government
- National Natural Science Foundation of China
- Government
- National Institutes of Health
- Government
- National Cancer Institute
- Government
- NCI NIH HHS
- Grants
- National Natural Science Foundation of China (81402734); U.S. Department of Defense (DAMD 17-02-1-0607); National Cancer Institute (R01 CA 118229); National Natural Science Foundation of China (17-02); National Cancer Institute (CA118229); National Institutes of Health (R01 CA118229)
Based on 5 listed funder(s).
Publication
- Published
- 2021-10-19 · Int J Cancer · vol. 150 · issue 4 · pp. 572–579
- Publisher
- Wiley
- Cited
- 16 citations · more than 73% of similar papers · 1.0× the field average
- References
- 39 works
- Access
- Free to read
- Research areas
- Nuts composition and effects · Nutritional Studies and Diet · Tea Polyphenols and Effects
- Keywords
- Breast cancer, Medicine, Disease, Demography, Consumption (sociology), Cancer, Term (time), Internal medicine, Environmental health, Gerontology, Oncology
- MeSH
- humans, nuts, breast neoplasms, neoplasm recurrence, local, neoplasm staging, proportional hazards models, energy intake, adult, aged, middle aged, female, cancer survivors
7 authors
From US, CN
- Cong WangVanderbilt University Medical Center
- Kai GuShanghai Municipal Center For Disease Control Prevention
- Fei WangSecond Hospital of Shandong University; Vanderbilt University Medical Center
- Hui CaiVanderbilt University Medical Center
- Wei ZhengVanderbilt University Medical Center
- Ping‐Ping BaoShanghai Municipal Center For Disease Control Prevention
Abstract
High nut consumption is associated with reduced total and certain cause-specific mortality in general populations. However, its association with cancer outcomes among long-term breast cancer survivors remains unknown. We examined the associations of nut consumption (including peanuts and tree nuts), assessed at 5-year postdiagnosis, with overall survival (OS) and disease-free survival (DFS) among 3449 long-term breast cancer survivors from the Shanghai Breast Cancer Survival Study, applying Cox regression analysis. During a median follow-up of 8.27 years post dietary assessment, there were 374 deaths, including 252 breast cancer deaths. Among 3274 survivors without previous recurrence at the dietary assessment, 209 developed breast cancer-specific events, that is, recurrence, metastasis or breast cancer mortality. At 5-year post dietary assessment (ie, 10-year postdiagnosis), regular nut consumers had higher OS (93.7% vs 89.0%) and DFS (94.1% vs 86.2%) rates. After multivariable adjustment, nut consumption was positively associated with OS (Ptrend = .022) and DFS (Ptrend = .003) following a dose-response pattern, with hazard ratios (95% confidence interval) of 0.72 (0.52-1.05) for OS and 0.48 (0.31-0.73) for DFS, for participants with greater than median nut intake compared with nonconsumers. The associations did not vary by nut type. Stratified analyses showed that the associations were more evident among participants with a higher total energy intake for OS (Pinteraction = .02) and among participants with early stage (I-II) breast cancers for DFS (Pinteraction = .04). The nut-DFS associations were not modified by estrogen receptor/progesterone receptor status or other known prognostic factors. In conclusion, nut consumption was associated with better survival, particularly DFS, among long-term breast cancer survivors.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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