Effects of magnesium supplementation on post-thyroidectomy hypocalcemia: a prospective single-center study
Minuto MN, Santori G, Ansaldo GL, Solari N, Boschetti M, Tassone C, Barbieri S, Reina S, Mascherini M, Varaldo E
Minerva endocrinology · 1 citation
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2021-10-20 · Minerva Endocrinol (Torino) · vol. 49 · issue 2 · pp. 132–140
- Publisher
- Edizioni Minerva Medica
- Cited
- 3 citations · more than 68% of similar papers · 0.6× the field average
- References
- 24 works
- Access
- Paywalled
- Research areas
- Thyroid and Parathyroid Surgery · Parathyroid Disorders and Treatments · Magnesium in Health and Disease
- Keywords
- Medicine, Hypomagnesemia, Contraindication, Hypoparathyroidism, Thyroidectomy, Surgery, Prospective cohort study, Parathyroid hormone, Magnesium, Single Center, Thyroid, Gastroenterology, Calcium, Internal medicine
- MeSH
- humans, hypocalcemia, hypoparathyroidism, postoperative complications, calcium, magnesium, thyroidectomy, prospective studies, dietary supplements, adult, aged, middle aged, female, male
10 authors
From US, IT
- Michele N Minuto · correspondingMartin University; Ospedale Policlinico San Martino; University of Genoa
- Gregorio SantoriUniversity of Genoa
- Gian Luca AnsaldoMartin University; Ospedale Policlinico San Martino
- Nicola SolariMartin University; Ospedale Policlinico San Martino
- Mara BoschettiMartin University; Ospedale Policlinico San Martino; University of Genoa
- Caterina TassoneMartin University; Ospedale Policlinico San Martino
Abstract
Background
Severe and/or symptomatic hypocalcemia due to hypoparathyroidism is the main contraindication for discharge in patients who have undergone thyroid surgery. Hypomagnesemia may contribute to the onset of hypoparathyroidism and is frequently observed after thyroid surgery in hypocalcemic patients. The impact of prophylactic and postoperative Magnesium supplementation on postoperative hypocalcemia and hypomagnesemia was prospectively evaluated by comparing patients undergoing prophylactic supplementation to a control group of patients who had only received magnesium after evidence of postoperative hypomagnesemia.
Methods
One hundred and twenty patients who underwent a total thyroidectomy participated in the study. Seventy-three patients were included in the study group, 47 in the control group. Prior to surgery, patients in the study group were given magnesium orally for 5 days; postoperatively, calcium and magnesium was administered to all patients who displayed hypocalcemia and hypomagnesemia.
Results
Postoperative biochemical hypocalcemia (serum calcium <8.5 mg/dL, regardless of its clinical severity) was found in 60 patients (50%) on D1 and in 58 patients (48.4%) on D2. Among hypocalcemic patients, hypomagnesemia was recorded in 29 at D1 (48%), and in 46 at D2 (79%). A significant positive correlation was found between magnesium, calcium, and parathyroid hormone in the first two postoperative days, while a significant inverse correlation occurred for these same parameters and length of hospital stay (P<0.001). One hundred and five patients (87.5%) were discharged as expected on the second postoperative day (65 in the study group, 40 in the control group, P=0.724), whereas 15 patients (12.5%) required prolonged hospitalization (eight in the study group, seven in the control group, P=0.721). The Study group only showed significantly higher magnesium levels on the first postoperative day (P=0.03).
Conclusions
Although magnesium and calcium levels showed the same trend after thyroidectomy, neither Magnesium prophylaxis nor Magnesium treatment influenced the clinical course of postoperative hypocalcemia.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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