Effect of Ashwagandha Withanolides on Muscle Cell Differentiation
Wang J, Zhang H, Kaul A, Li K, Priyandoko D, Kaul SC, Wadhwa R
Biomolecules · 18 citations
How it was studied
- Design
- In vitro/mechanistic study (classified by our AI screen)
- Studied in
- People, plus animal or lab work
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- National Institute of Advanced Industrial Science and Technology
- Government
- Department of Biotechnology, Ministry of Science and Technology, India
- Grants
- National Institute of Advanced Industrial Science and Technology (BT/BI/14/042/2017); Department of Biotechnology, Ministry of Science and Technology, India (BT/BI/14/042/2017)
Based on 2 listed funder(s).
Publication
- Published
- 2021-10-04 · Biomolecules · vol. 11 · issue 10 · p. 1454
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 27 citations · more than 92% of similar papers · 3.3× the field average
- Impact
- Top 10% most cited in its field
- References
- 90 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Phytochemicals and Medicinal Plants · Medicinal Plants and Neuroprotection
- Keywords
- Chemistry, Biology
- MeSH
- cell line, muscle cells, animals, humans, mice, parkinson disease, plant extracts, medicine, ayurvedic, cell differentiation, withanolides
7 authors
From JP, CN, ID
- Jia WangNational Institute of Advanced Industrial Science and Technology
- Huayue ZhangNational Institute of Advanced Industrial Science and Technology
- Ashish KaulNational Institute of Advanced Industrial Science and Technology
- Kejuan LiSichuan Normal University; National Institute of Advanced Industrial Science and Technology
- Didik PriyandokoIndonesia University of Education; National Institute of Advanced Industrial Science and Technology
- Sunil C. KaulNational Institute of Advanced Industrial Science and Technology
Abstract
Withania somnifera (Ashwagandha) is used in Indian traditional medicine, Ayurveda, and is believed to have a variety of health-promoting effects. The molecular mechanisms and pathways underlying these effects have not yet been sufficiently explored. In this study, we investigated the effect of Ashwagandha extracts and their major withanolides (withaferin A and withanone) on muscle cell differentiation using C2C12 myoblasts. We found that withaferin A and withanone and Ashwagandha extracts possessing different ratios of these active ingredients have different effects on the differentiation of C2C12. Withanone and withanone-rich extracts caused stronger differentiation of myoblasts to myotubes, deaggregation of heat- and metal-stress-induced aggregated proteins, and activation of hypoxia and autophagy pathways. Of note, the Parkinson's disease model of Drosophila that possess a neuromuscular disorder showed improvement in their flight and climbing activity, suggesting the potential of Ashwagandha withanolides for the management of muscle repair and activity.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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