Higher intake of whole grains and dietary fiber are associated with lower risk of liver cancer and chronic liver disease mortality
Liu X, Yang W, Petrick JL, Liao LM, Wang W, He N, Campbell PT, Zhang ZF, Giovannucci E, McGlynn KA, Zhang X
Nature communications · 75 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- Government
- U.S. Department of Health and Human Services
- Nonprofit
- American Cancer Society
- Government
- U.S. Department of State
- Government
- Pennsylvania Department of Health
- Government
- Florida Department of Health
- University or hospital
- Emory University
- Government
- Arizona Department of Health Services
- University or hospital
- Dana-Farber/Harvard Cancer Center
- University or hospital
- Louisiana State University
- University or hospital
- Harvard T.H. Chan School of Public Health
- Government
- Missouri Department of Health and Senior Services
- Government
- Texas Department of State Health Services
- Government
- National Institutes of Health
- Government
- National Cancer Institute
- Government
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Government
- NCI NIH HHS
- Government
- the Intramural Research Program of Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
- Grants
- American Cancer Society (NEC-130476); National Cancer Institute (K07 CA188126); Division of Cancer Epidemiology and Genetics, National Cancer Institute (K07 CA188126); National Cancer Institute (CA188126); National Institutes of Health (R21 CA238651); National Institutes of Health (CA188126); National Institutes of Health (K07CA188126); National Cancer Institute (R21 CA238651)
Based on 17 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2021-11-04 · Nat Commun · vol. 12 · issue 1 · p. 6388
- Publisher
- Nature Portfolio
- Cited
- 98 citations · more than 99% of similar papers · 9.1× the field average
- Impact
- Top 10% most cited in its field
- References
- 57 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Liver Disease Diagnosis and Treatment · Nutritional Studies and Diet · Food Security and Health in Diverse Populations
- Keywords
- Medicine, Liver cancer, Hazard ratio, Internal medicine, Chronic liver disease, Whole grains, Cancer, Liver disease, Refined grains, Proportional hazards model, Disease, Confidence interval, Cohort, Cohort study, Gastroenterology, Cirrhosis, Biology, Food science
- MeSH
- humans, liver neoplasms, liver diseases, proportional hazards models, eating, dietary fiber, aged, middle aged, female, male, surveys and questionnaires, edible grain
11 authors
From US, CN
- Xing LiuHarvard University; Fudan University
- Wanshui YangBrigham and Women's Hospital; Harvard University; Anhui Medical University
- Jessica L. PetrickBoston University
- Linda M. LiaoNational Cancer Institute; Division of Cancer Epidemiology and Genetics
- Weibing WangFudan University
- Na HeFudan University
Abstract
The relationship between dietary factors and liver disease remains poorly understood. This study evaluated the associations of whole grain and dietary fiber intake with liver cancer risk and chronic liver disease mortality. The National Institutes of Health-American Association of Retired Persons Diet and Health Study cohort recruited 485, 717 retired U.S. participants in 1995-1996. Follow-up through 2011 identified 940 incident liver cancer cases and 993 deaths from chronic liver disease. Compared with the lowest, the highest quintile of whole grain intake was associated with lower liver cancer risk (Hazard ratio [HR]Q5 vs. Q1 = 0.78, 95% confidence interval [CI]: 0.63-0.96) and chronic liver disease mortality (HRQ5 vs. Q1 = 0.44, 95% CI: 0.35-0.55) in multivariable Cox models. Dietary fiber was also associated with lower liver cancer risk (HRQ5 vs. Q1 = 0.69, 95% CI: 0.53-0.90) and chronic liver disease mortality (HRQ5 vs. Q1 = 0.37, 95% CI: 0.29-0.48). Fiber from vegetables, beans and grains showed potential protective effect. Here, we show that higher intake of whole grain and dietary fiber are associated with lower risk of liver cancer and liver disease mortality.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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