Funded in part by Novo Nordisk, Novo Nordisk Fonden, Novo Nordisk Foundation Center for Basic Metabolic Research, Novo Nordisk Foundation
Altered brown fat thermoregulation and enhanced cold-induced thermogenesis in young, healthy, winter-swimming men
Søberg S, Löfgren J, Philipsen FE, Jensen M, Hansen AE, Ahrens E, Nystrup KB, Nielsen RD, Sølling C, Wedell-Neergaard AS, Berntsen M, Loft A, Kjær A, Gerhart-Hines Z, Johannesen HH, Pedersen BK, Karstoft K, Scheele C
Cell reports. Medicine · 42 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cross-sectional study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Industry funded
- Government
- European Commission
- University or hospital
- Københavns Universitet
- University or hospital
- Gentofte Hospital
- Company
- Novo Nordisk
- University or hospital
- Rigshospitalet
- University or hospital
- Copenhagen Graduate School for Nanoscience and Nanotechnology
- Nonprofit
- TrygFonden
- Company
- Novo Nordisk Fonden
- Company
- Novo Nordisk Foundation Center for Basic Metabolic Research
- Government
- Horizon 2020 Framework Programme
- Government
- European Research Council
- Government
- Horizon 2020
- Government
- H2020 European Research Council
- Company
- Novo Nordisk Foundation
- University or hospital
- NNF Center for Basic Metabolic Research
- Authors
- At least one author declares a financial tie to industry
- Grants
- H2020 European Research Council (639382); TrygFonden (20045); TrygFonden (101390); European Commission (HORIZON2020); Novo Nordisk Fonden (NNF 18 CC0034900); Novo Nordisk Foundation Center for Basic Metabolic Research (NNF 18 CC0034900); Rigshospitalet (E-22793-05); Novo Nordisk Fonden (NNF17OC0029918); Novo Nordisk (NNF18CC0034900)
Based on 15 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2021-10-01 · Cell Rep Med · vol. 2 · issue 10 · p. 100408
- Publisher
- Elsevier BV
- Cited
- 70 citations · more than 97% of similar papers · 5.1× the field average
- Impact
- Top 10% most cited in its field
- References
- 76 works
- Access
- Open access (journal) · CC-BY-NC-ND
- Research areas
- Adipose Tissue and Metabolism · Exercise and Physiological Responses · Thermoregulation and physiological responses
- Keywords
- Thermoregulation, Thermogenesis, Brown adipose tissue, Skin temperature, Energy expenditure, Cold winter, Nocturnal, Acclimatization, Biology, Core temperature, Animal science, Medicine, Endocrinology, Internal medicine, Ecology, Adipose tissue, Meteorology
- MeSH
- humans, hormones, positron-emission tomography, magnetic resonance imaging, thermography, perception, seasons, thermogenesis, skin temperature, circadian rhythm, swimming, adult, male, adipose tissue, brown, cold temperature, young adult
18 authors
From DK
- Susanna SøbergUniversity of Copenhagen; Novo Nordisk Foundation; Rigshospitalet
- Johan LöfgrenUniversity of Copenhagen; Rigshospitalet
- Frederik E. PhilipsenUniversity of Copenhagen; Rigshospitalet
- Michal JensenUniversity of Copenhagen; Rigshospitalet
- Adam Espe HansenUniversity of Copenhagen; Rigshospitalet
- Esben AhrensRigshospitalet
Abstract
The Scandinavian winter-swimming culture combines brief dips in cold water with hot sauna sessions, with conceivable effects on body temperature. We study thermogenic brown adipose tissue (BAT) in experienced winter-swimming men performing this activity 2-3 times per week. Our data suggest a lower thermal comfort state in the winter swimmers compared with controls, with a lower core temperature and absence of BAT activity. In response to cold, we observe greater increases in cold-induced thermogenesis and supraclavicular skin temperature in the winter swimmers, whereas BAT glucose uptake and muscle activity increase similarly to those of the controls. All subjects demonstrate nocturnal reduction in supraclavicular skin temperature, whereas a distinct peak occurs at 4:30-5:30 a.m. in the winter swimmers. Our data leverage understanding of BAT in adult human thermoregulation, suggest both heat and cold acclimation in winter swimmers, and propose winter swimming as a potential strategy for increasing energy expenditure.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-ND).
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