Resting-state language network neuroplasticity in post-stroke music listening: A randomized controlled trial
Sihvonen AJ, Pitkäniemi A, Leo V, Soinila S, Särkämö T
The European journal of neuroscience · 14 citations
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- Academy of Finland
- Nonprofit
- Suomen Kulttuurirahasto
- Nonprofit
- Signe ja Ane Gyllenbergin Säätiö
- Nonprofit
- Orionin Tutkimussäätiö
- Nonprofit
- Suomen Aivosäätiö
- University or hospital
- Turun Yliopistollisen Keskussairaalan Koulutus- ja Tutkimussäätiö
- Nonprofit
- Suomen Aivotutkimus- ja Kuntoutussäätiö
- Government
- H2020 European Research Council
- Government
- European Research Council
- Grants
- Turun Yliopistollisen Keskussairaalan Koulutus- ja Tutkimussäätiö (13944); Academy of Finland (257077); H2020 European Research Council (803466); Suomen Kulttuurirahasto (#191230); Academy of Finland (277693); Academy of Finland (299044)
Based on 9 listed funder(s).
Publication
- Published
- 2021-11-11 · Eur J Neurosci · vol. 54 · issue 11 · pp. 7886–7898
- Publisher
- Wiley
- Cited
- 21 citations · more than 76% of similar papers · 1.2× the field average
- References
- 71 works
- Access
- Open access (repository copy)
- Research areas
- Neuroscience and Music Perception · Neurobiology of Language and Bilingualism · Music Therapy and Health
- Keywords
- Neuroplasticity, Randomized controlled trial, Active listening, Stroke (engine), Psychology, Resting state fMRI, Physical medicine and rehabilitation, Neuroscience, Medicine, Communication, Internal medicine
- MeSH
- humans, magnetic resonance imaging, single-blind method, language, neuronal plasticity, music, stroke
5 authors
From FI, AU
- Aleksi J. Sihvonen · correspondingUniversity of Helsinki; The University of Queensland
- Anni PitkäniemiUniversity of Helsinki
- Vera LeoUniversity of Helsinki
- Seppo O. SoinilaUniversity of Turku; Turku University Hospital
- Teppo SärkämöUniversity of Helsinki
Abstract
Recent evidence suggests that post-stroke vocal music listening can aid language recovery, but the network-level functional neuroplasticity mechanisms of this effect are unknown. Here, we sought to determine if improved language recovery observed after post-stroke listening to vocal music is driven by changes in longitudinal resting-state functional connectivity within the language network. Using data from a single-blind randomized controlled trial on stroke patients (N = 38), we compared the effects of daily listening to self-selected vocal music, instrumental music and audio books on changes of the resting-state functional connectivity within the language network and their correlation to improved language skills and verbal memory during the first 3 months post-stroke. From acute to 3-month stage, the vocal music and instrumental music groups increased functional connectivity between a cluster comprising the left inferior parietal areas and the language network more than the audio book group. However, the functional connectivity increase correlated with improved verbal memory only in the vocal music group cluster. This study shows that listening to vocal music post-stroke promotes recovery of verbal memory by inducing changes in longitudinal functional connectivity in the language network. Our results conform to the variable neurodisplacement theory underpinning aphasia recovery.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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