Egg and Dietary Cholesterol Consumption and Mortality Among Hypertensive Patients: Results From a Population-Based Nationwide Study
Wu F, Zhuang P, Zhang Y, Zhan C, Zhang Y, Jiao J
Frontiers in nutrition · 7 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Food diaries or recalls
Who paid for it
- Funding
- Independent funding
- Government
- National Natural Science Foundation of China
- Government
- National Institute for Nutrition and Health
- Government
- National Institutes of Health
- University or hospital
- China-Japan Friendship Hospital
- Government
- Fogarty International Center
- Government
- National Institute of Diabetes and Digestive and Kidney Diseases
- Government
- National Institute of Child Health and Human Development
- Government
- Eunice Kennedy Shriver National Institute of Child Health and Human Development
- Grants
- Eunice Kennedy Shriver National Institute of Child Health and Human Development ([P2C HD050924]); China-Japan Friendship Hospital (P2C HD050924); China-Japan Friendship Hospital (D43 TW009077); National Institute of Child Health and Human Development (P2CHD050924); Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01DK104371); National Institute of Diabetes and Digestive and Kidney Diseases (D43 TW009077); Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD30880); National Institute of Diabetes and Digestive and Kidney Diseases (R01 HD30880); Eunice Kennedy Shriver National Institute of Child Health and Human Development (D43 TW009077); National Institute of Child Health and Human Development (R01-HD30880); National Institute for Nutrition and Health (D43 TW009077); National Institute of Diabetes and Digestive and Kidney Diseases (R01- DK104371); National Institute for Nutrition and Health (P2C HD050924); Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01 HD 30880); Fogarty International Center (R01-HD30880); Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD050924); Fogarty International Center (P2C HD050924); Fogarty International Center (D43‐TW009077); National Institutes of Health (#P2C HD050924); National Institutes of Health (R01 HD30880); National Institutes of Health (HD30880); National Institutes of Health (#HD050924); National Institutes of Health (R01-DK104371); National Institutes of Health (D43-TW-009077)
Based on 8 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2021-10-29 · Front Nutr · vol. 8 · p. 739533
- Publisher
- Frontiers Media
- Cited
- 9 citations · more than 81% of similar papers · 1.3× the field average
- References
- 55 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Nutritional Studies and Diet · Diet and metabolism studies · Consumer Attitudes and Food Labeling
- Keywords
- Medicine, Cholesterol, Dietary Cholesterol, Hazard ratio, Proportional hazards model, Cohort study, Cohort, Population, Demography, Internal medicine, Environmental health, Confidence interval
6 authors
From CN
- Fei Ling WuSecond Affiliated Hospital of Zhejiang University
- Pan ZhuangZhejiang University
- Yiju ZhangZhejiang University
- Chuchu ZhanZhejiang University
- Yu ZhangZhejiang University
- Jingjing Jiao · correspondingSecond Affiliated Hospital of Zhejiang University
Abstract
Background: Hypertensive patients are sensitive to the amount of dietary cholesterol intake, especially cholesterol from the whole eggs. Whether whole egg and dietary cholesterol consumption are suitable for hypertensive patients is still controversial. Aim: The objective of the study was to examine the associations of intake of eggs as well as the dietary cholesterol with total mortality in a Chinese nationwide cohort. Methods: We utilized data from the China Health and Nutrition Survey (CHNS) from the year of 1991 to 2015. Cumulative averages of egg and cholesterol intake were calculated to represent the consumption of the long-term diet of the participants in each available round of the survey. Cox regression models were employed to estimate the effects of eggs and dietary cholesterol from the different sources on mortality among hypertensive patients. Results: A total of 8,095 participants were included in the final analysis and followed up for a mean of 11.4 years. Finally, 927 cases of death were detected. After adjustment for the multivariate factors, consuming more than seven eggs per week was related to 29% lower mortality among the hypertensive patients compared with the consumers with not more than two eggs per week [hazard ratio (HR): 0.71; 95% CI: 0.59-0.85; P P = 0.002) whereas intake of the dietary cholesterol from the non-egg sources was significantly related to the higher mortality (P Conclusion: Higher consumption of eggs and egg-sourced dietary cholesterol was associated with lower mortality among the enrolled Chinese hypertensive patients but non-egg-sourced cholesterol intake was related to higher mortality. Therefore, our findings do not support the view that hypertensive patients should avoid whole egg consumption for the purpose of restricting dietary cholesterol intake.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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