Effects of whole grain intake on glycemic traits: A systematic review and meta-analysis of randomized controlled trials
Li S, Zong A, An R, Wang H, Liu L, Liu J, Guo X, Xu Z, Wang J, Li D, Du F, Xu T
Critical reviews in food science and nutrition · 15 citations
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- University or hospital
- Beijing Advanced Innovation Center for Food Nutrition and Human Health
- University or hospital
- Open Project Program of China-Canada Joint Lab of Food Nutrition and Health, Beijing Technology and Business University
- Government
- National Key R & D Project
- Grants
- Beijing Advanced Innovation Center for Food Nutrition and Human Health (20171030)
Based on 3 listed funder(s).
Publication
- Published
- 2021-11-18 · Crit Rev Food Sci Nutr · vol. 63 · issue 20 · pp. 4351–4370
- Publisher
- Taylor & Francis
- Cited
- 24 citations · more than 66% of similar papers · 0.8× the field average
- References
- 74 works
- Access
- Open access (repository copy) · CC-BY
- Research areas
- Food composition and properties · Nutritional Studies and Diet · Diet and metabolism studies
- Keywords
- Meta-analysis, Glycemic, Randomized controlled trial, Whole grains, Medicine, Glycemic index, Food science, Internal medicine, Biology, Insulin
- MeSH
- humans, diabetes mellitus, type 2, insulin resistance, insulin, blood glucose, randomized controlled trials as topic, whole grains, glycated hemoglobin
12 authors
From CN
- Shixiang LiShandong Academy of Agricultural Sciences; Ministry of Agriculture and Rural Affairs; Shandong Agricultural University
- Aizhen ZongShandong Academy of Agricultural Sciences; Ministry of Agriculture and Rural Affairs; Shandong Agricultural University
- Ran AnShandong Normal University; Shandong Academy of Agricultural Sciences; Ministry of Agriculture and Rural Affairs
- Haiou WangShandong Academy of Agricultural Sciences; Ministry of Agriculture and Rural Affairs
- Lina LiuShandong Academy of Agricultural Sciences; Ministry of Agriculture and Rural Affairs
- Jie LiuBeijing Technology and Business University
Abstract
Whole grains (WGs) may have various health benefits, including lowering blood glucose and improving insulin sensitivity. To conduct a meta-analysis of the effects of WGs compared with non-WGs on changes in fasting glucose, fasting insulin, glycated hemoglobin (HbA1c), and homeostasis model assessment of insulin resistance (HOMA-IR). A systematic literature search was performed for all published randomized controlled trials on the effects of WG intake on fasting glucose, fasting insulin, HbA1c and HOMA-IR response up to February 2021. Weighted mean differences (WMD) were calculated. Pre-specified subgroup and univariate meta-regression analyses were explored to identify the sources of heterogeneity. Sensitivity analysis and bias analysis were conducted to appraise study quality. Among 12,435 articles screened for eligibility, data were extracted from 48 articles. Meta-analysis of 4,118 participants showed that WG consumption resulted in a significant reduction in fasting glucose by -0.15 mmol/L, fasting insulin by -2.71 pmol/L, HbA1c by -0.44%, and HOMA-IR by -0.28, respectively. Compared with mixed grains, brown rice, and wheat, oats were significantly lower on marker of glycemic. Besides, multiple interventions per day consolidated effectiveness of WGs. WG consumption decreased the levels of fasting glucose, fasting insulin, HbA1c, and HOMA-IR compared with non-WG consumption.Supplemental data for this article is available online at https://doi.org/10.1080/10408398.2021.2001429 .
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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