Diversity in blueberry genotypes and developmental stages enables discrepancy in the bioactive compounds, metabolites, and cytotoxicity
Das PR, Darwish AG, Ismail A, Haikal AM, Gajjar P, Balasubramani SP, Sheikh MB, Tsolova V, Soliman KFA, Sherif SM, El-Sharkawy I
Food chemistry · 19 citations
How it was studied
- Design
- In vitro/mechanistic study (classified by our AI screen)
- Studied in
- Cells or lab samples
- Main outcome
- No health outcome
Who paid for it
- Funding
- Independent funding
- Government
- U.S. Department of Agriculture
- Government
- National Institute of Food and Agriculture
- University or hospital
- Fakultät für Geowissenschaften, Geographie und Astronomie, Universität Wien
- Government
- National Institute on Minority Health and Health Disparities
- Government
- NIMHD NIH HHS
- Grants
- National Institute on Minority Health and Health Disparities (U54 MD 007582); National Institute of Food and Agriculture (1021741); National Institute of Food and Agriculture (2020-38821-31086)
Based on 5 listed funder(s).
Publication
- Published
- 2021-11-18 · Food Chem · vol. 374 · p. 131632
- Publisher
- Elsevier BV
- Cited
- 48 citations · more than 90% of similar papers · 2.4× the field average
- Impact
- Top 10% most cited in its field
- References
- 43 works
- Access
- Open access (hybrid journal) · CC-BY-NC-ND
- Research areas
- Phytochemicals and Antioxidant Activities · Plant Gene Expression Analysis · Plant biochemistry and biosynthesis
- Keywords
- Nutraceutical, Quinic acid, Chlorogenic acid, Metabolite, Cultivar, Metabolomics, Malic acid, Biology, Ellagic acid, Primary metabolite, Food science, Chemistry, Antioxidant, Biochemistry, Botany, Polyphenol, Citric acid, Chromatography
- MeSH
- caco-2 cells, humans, phenols, antioxidants, genotype, blueberry plants
11 authors
From US, EG
- Protiva Rani DasFlorida Agricultural and Mechanical University; Virginia Tech
- Ahmed G. DarwishFlorida Agricultural and Mechanical University; Minia University
- Ahmed IsmailDamanhour University; Florida Agricultural and Mechanical University
- Amr M. HaikalDamanhour University
- Pranavkumar GajjarFlorida Agricultural and Mechanical University
- Subramani Paranthaman BalasubramaniAlbany State University; Florida Agricultural and Mechanical University
Abstract
Eight blueberry cultivars at three developmental stages were investigated for metabolite profiling, antioxidant, and anticancer activities. Cultivars- and developmental stages-variations were determined in total phenolic, flavonoid, DPPH, and FRAP antioxidant assays. The anticancer capacity was equal against A549, HepG2, and Caco-2 cancer cells, whereas the inhibition rate was dose-, incubation period-, cultivar-, and developmental stages-dependent. The untargeted metabolite profiling by UPLC-TOF-MS analysis of two contrast cultivars, 'Vernon' and 'Star', throughout the developmental stages revealed 328 metabolites; the majority of them were amino acids, organic acids, and flavonoids. The multivariate statistical analysis identified five metabolites, including quinic acid, methyl succinic acid, chlorogenic acid, oxoadipic acid, and malic acid, with positively higher correlations with all anticancer activities. This comprehensive database of blueberry metabolites along with anticancer activities could be targeted as natural anticancer potentials. This study would be of great value for food, nutraceutical, and pharmaceutical industries as well as plant biotechnologists.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-ND).
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