Oral Magnesium Supplementation for Treating Glucose Metabolism Parameters in People with or at Risk of Diabetes: A Systematic Review and Meta-Analysis of Double-Blind Randomized Controlled Trials
Veronese N, Dominguez LJ, Pizzol D, Demurtas J, Smith L, Barbagallo M
Nutrients · 38 citations
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
Based on full-text disclosure statement.
Publication
- Published
- 2021-11-15 · Nutrients · vol. 13 · issue 11 · p. 4074
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 59 citations · more than 77% of similar papers · 1.2× the field average
- References
- 70 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments · Aluminum toxicity and tolerance in plants and animals
- Keywords
- Diabetes mellitus, Medicine, Placebo, Internal medicine, Endocrinology, Insulin, Randomized controlled trial, Insulin sensitivity, Confidence interval, Insulin resistance
- MeSH
- humans, diabetes mellitus, insulin resistance, magnesium, blood glucose, glucose tolerance test, treatment outcome, double-blind method, dietary supplements, randomized controlled trials as topic
6 authors
From IT, NO, GB
- Nicola Veronese · correspondingUniversity of Palermo
- Ligia Juliana DominguezUniversità degli Studi di Enna Kore; University of Palermo
- Damiano PizzolNorwegian Agency for Development Cooperation
- Jacopo DemurtasUniversity of Modena and Reggio Emilia
- Lee H. SmithAnglia Ruskin University
- Mario BarbagalloUniversity of Palermo
Abstract
There is a large and growing body of literature focusing on the use of oral magnesium (Mg) supplementation for improving glucose metabolism in people with or at risk of diabetes. We therefore aimed to investigate the effect of oral Mg supplementation on glucose and insulin-sensitivity parameters in participants with diabetes or at high risk of diabetes, compared with a placebo. Several databases were searched investigating the effect of oral Mg supplementation vs placebo in patients with diabetes or conditions at high risk of diabetes. Data were reported as standardized mean differences (SMDs) with their 95% confidence intervals (CIs) using follow-up data of glucose and insulin-sensitivity parameters. Compared with placebo, Mg supplementation reduced fasting plasma glucose in people with diabetes. In people at high risk of diabetes, Mg supplementation significantly improved plasma glucose per se, and after a 2 h oral glucose tolerance test. Furthermore, Mg supplementation demonstrated an improvement in insulin sensitivity markers. In conclusion, Mg supplementation appears to have a beneficial role and improves glucose parameters in people with diabetes. Moreover, our work indicates that Mg supplementation may improve insulin-sensitivity parameters in those at high risk of diabetes.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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