Drug-induced hepatocellular injury due to herbal supplement ashwagandha
Ireland PJ, Hardy T, Burt AD, Donnelly MC
The journal of the Royal College of Physicians of Edinburgh · 18 citations
How it was studied
- Design
- Case report (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- Medical Research Council
- Grants
- Medical Research Council (MR/N005872/1)
Based on 1 listed funder(s).
Publication
- Published
- 2021-12-01 · J R Coll Physicians Edinb · vol. 51 · issue 4 · pp. 363–366
- Publisher
- SAGE Publishing
- Cited
- 26 citations · more than 89% of similar papers · 2.5× the field average
- References
- 6 works
- Access
- Paywalled
- Research areas
- Drug-Induced Hepatotoxicity and Protection · Poisoning and overdose treatments · Complementary and Alternative Medicine Studies
- Keywords
- Medicine, Liver injury, Jaundice, Ursodeoxycholic acid, Toxic hepatitis, Drug, Liver biopsy, Nausea, Internal medicine, Hepatitis, Gastroenterology, Traditional medicine, Biopsy, Pharmacology
- MeSH
- humans, carcinoma, hepatocellular, liver neoplasms, plant extracts, dietary supplements, adult, female
4 authors
From GB
- Peter J. IrelandFreeman Hospital
- Timothy HardyFreeman Hospital
- Alastair D. BurtRoyal Victoria Infirmary
- Mhairi Claire Donnelly · correspondingFreeman Hospital
Abstract
A 39-year-old female presented with a one-week history of jaundice and nausea after taking an over-the-counter herbal supplement containing ashwagandha root extract. Initial investigations revealed a hepatocellular pattern of liver enzyme abnormality with jaundice. Investigations, including viral serology, liver specific autoantibodies and an ultrasound scan of the abdomen, were unremarkable. Liver biopsy showed an acute cholestatic hepatitis with confluent necrosis but no features of chronicity. These histopathological findings differ to that of a previously reported case. Review of recent literature revealed that some clinical features and the time course of liver injury were similar to previous reports of ashwagandha drug-induced liver injury (DILI). The patient received treatment with ursodeoxycholic acid. We compare this case to previous reported cases of ashwagandha DILI and discuss the biochemical and histopathological features of ashwagandha DILI, therapeutic strategies and the importance of recognising herbal supplements as a possible cause of DILI.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.