Serum and plasma brain-derived neurotrophic factor concentration are elevated by systemic but not local passive heating
Ogawa T, Hoekstra SP, Kamijo YI, Goosey-Tolfrey VL, Walsh JJ, Tajima F F, Leicht CA
PloS one · 8 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Mechanisms only
Who paid for it
- Funding
- Independent funding
- Government
- National Institute for Health and Care Research
- University or hospital
- NIHR Leicester Biomedical Research Centre
- University or hospital
- leicester biomedical research centre
- University or hospital
- Kyoten Research Center of Sports for Persons with Impairments
Based on 4 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2021-12-09 · PLoS One · vol. 16 · issue 12 · p. e0260775
- Publisher
- Public Library of Science
- Cited
- 11 citations · more than 65% of similar papers · 0.6× the field average
- References
- 49 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Thermoregulation and physiological responses · Infrared Thermography in Medicine · Heart Rate Variability and Autonomic Control
- Keywords
- Internal medicine, Brain-derived neurotrophic factor, Endocrinology, Platelet, Chemistry, Neurotrophic factors, Blood plasma, Whole blood, Medicine
- MeSH
- lower extremity, humans, brain-derived neurotrophic factor, heating, body temperature regulation, adult, male, cold temperature, young adult
7 authors
From JP, GB, CA
- Takahiro OgawaWakayama Medical University
- Sven P. HoekstraLoughborough University
- Yoshi‐ichiro KamijoWakayama Medical University
- Victoria Louise Goosey-TolfreyLoughborough University
- Jeremy James WalshMcMaster University
- Fumihiro TajimaLoughborough University; Wakayama Medical University
Abstract
Brain-derived neurotrophic factor (BDNF) plays a key role in neuronal adaptations. While previous studies suggest that whole-body heating can elevate circulating BDNF concentration, this is not known for local heating protocols. This study investigated the acute effects of whole-body versus local passive heating on serum and plasma BDNF concentration. Using a water-perfused suit, ten recreationally active males underwent three 90 min experimental protocols: heating of the legs with upper-body cooling (LBH), whole-body heating (WBH) and a control condition (CON). Blood samples were collected before, immediately after and 1 h post-heating for the determination of serum and plasma BDNF concentration, platelet count as well as the BDNF release per platelet. Rectal temperature, cardiac output and femoral artery shear rate were assessed at regular intervals. Serum and plasma BDNF concentration were elevated after WBH (serum: 19.1±5.0 to 25.9±11.3 ng/ml, plasma: 2.74±0.9 to 4.58±2.0; p0.126), when compared with CON (serum: 18.6±6.4 to 16.8±3.4 ng/ml, plasma: 2.49±0.69 to 2.82±0.89 ng/ml); accompanied by an increase in platelet count (p<0.001). However, there was no change in BDNF content per platelet after either condition (p = 0.392). All physiological measures were elevated to a larger extent after WBH compared with LBH (p<0.001), while shear rate and rectal temperature were higher during LBH than CON (p<0.038). In conclusion, WBH but not LBH acutely elevates circulating BDNF concentration. While these findings further support the use of passive heating to elevate BDNF concentration, a larger increase in shear rate, sympathetic activity and/or rectal temperature than found after LBH appears needed to induce an acute BDNF response by passive heating.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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