Association of magnesium intake with sleep duration and sleep quality: findings from the CARDIA study
Zhang Y, Chen C, Lu L, Knutson KL, Carnethon MR, Fly AD, Luo J, Haas DM, Shikany JM, Kahe K
Sleep · 37 citations
How it was studied
- Design
- Cohort study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Possibly industry funded
- University or hospital
- Northwestern University
- University or hospital
- University of Minnesota
- University or hospital
- University of Alabama at Birmingham
- Government
- National Institutes of Health
- Company
- Kaiser Foundation Research Institute
- Government
- National Heart, Lung, and Blood Institute
- Government
- NHLBI NIH HHS
- Government
- NIH HHS
- Grants
- Northwestern University (HHSN268201800003I); National Heart, Lung, and Blood Institute (HHSN268201800004I); National Heart, Lung, and Blood Institute (R01 HL081572); University of Minnesota (HHSN268201800006I); National Heart, Lung, and Blood Institute (HHSN268201800005I); National Heart, Lung, and Blood Institute (HHSN268201800006I); University of Alabama at Birmingham (HHSN268201800005I); National Heart, Lung, and Blood Institute (HHSN268201800007I); National Heart, Lung, and Blood Institute (HHSN268201800003I); Kaiser Foundation Research Institute (HHSN268201800004I); University of Alabama at Birmingham (HHSN268201800007I); National Institutes of Health (R01HL081572)
Based on 8 listed funder(s).
Publication
- Published
- 2021-11-20 · Sleep · vol. 45 · issue 4
- Publisher
- Oxford University Press
- Cited
- 49 citations · more than 88% of similar papers · 2.3× the field average
- References
- 52 works
- Access
- Open access (repository copy)
- Research areas
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments · Sleep and related disorders
- Keywords
- Quartile, Confounding, Medicine, Odds ratio, Sleep (system call), Longitudinal study, Internal medicine, Generalized estimating equation, Confidence interval, Depression (economics)
- MeSH
- coronary vessels, humans, magnesium, diet, sleep, young adult, sleep wake disorders, sleep quality
10 authors
From US
- Yijia ZhangColumbia University
- Cheng ChenColumbia University
- Liping LüColumbia University
- Kristen L. KnutsonNorthwestern University; Circadian (United States)
- Mercedes R. CarnethonNorthwestern University
- Alyce D. FlyBall State University
Abstract
Study objectives
As an antagonist of calcium (Ca), magnesium (Mg) has been implicated in the regulation of sleep. We aimed to examine the longitudinal associations of Mg intake and Ca-to-Mg intake ratio (Ca:Mg) with sleep quality and duration.
Methods
The study sample consisted of 3,964 participants from the Coronary Artery Risk Development in Young Adults (CARDIA) study. Dietary and supplementary intake of Mg were obtained using the CARDIA Dietary History at baseline (1985-1986), exam years 7 and 20. Self-reported sleep outcomes were measured at years 15 and 20. Sleep quality was rating from 1 (very good) to 5 (very bad). We categorized sleep duration to 9 h. Generalized estimating equation was used to examine the associations of interest as repeated measures at the two time points.
Results
After adjustment for potential confounders, Mg intake was borderline associated with better sleep quality [highest quartile (Q4) vs. intake quartile (Q1): odds ratio (OR) = 1.23; 95% CI = 0.999, 1.50, ptrend = 0.051]. Participants in Q4 were also less likely to have short sleep (<7 h) compared to those in Q1 (OR = 0.64; 95% CI = 0.51, 0.81, ptrend = 0.012). The observed association with short sleep persisted among participants without depressive disorders (Q4 vs. Q1: OR = 0.64; 95% CI = 0.49, 0.82, ptrend < 0.001), but not among individuals with depressive disorder. Ca:Mg was not associated with either outcomes, regardless of depression status.
Conclusions
Mg intake was associated with both sleep outcomes in this longitudinal analysis. Randomized controlled trials with objective measures of sleep are warranted to establish the potential causal inference.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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