Dietary Magnesium Intake Affects the Association Between Serum Vitamin D and Type 2 Diabetes: A Cross-Sectional Study
Huang W, Ma X, Liang H, Li H, Chen J, Fang L, Yang Q, Zhang Z
Frontiers in nutrition · 37 citations
How it was studied
- Design
- Cross-sectional study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
- University or hospital
- Guangzhou Medical University
- Government
- Chinese People’s Liberation Army
- Grants
- Guangzhou Medical University (2020-LCYJ-XJS-08)
Based on 2 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2021-11-25 · Front Nutr · vol. 8 · p. 763076
- Publisher
- Frontiers Media
- Cited
- 47 citations · more than 94% of similar papers · 3.8× the field average
- Impact
- Top 10% most cited in its field
- References
- 39 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Magnesium in Health and Disease · Vitamin D Research Studies · Therapeutic Uses of Natural Elements
- Keywords
- Magnesium, Medicine, National Health and Nutrition Examination Survey, Vitamin D and neurology, Type 2 diabetes, Cross-sectional study, Diabetes mellitus, Incidence (geometry), Internal medicine, Vitamin, Dietary Reference Intake, Endocrinology, Nutrient, Environmental health, Population, Chemistry, Mathematics
8 authors
From CN
- Wei-Chao HuangSecond Affiliated Hospital of Guangzhou Medical University; Guangzhou Medical University
- Xiaoman MaThird Affiliated Hospital of Guangzhou Medical University; Guangzhou Medical University
- Hualiang LiangThird Affiliated Hospital of Guangzhou Medical University; Guangzhou Medical University
- Haojia LiThird Affiliated Hospital of Guangzhou Medical University; Guangzhou Medical University
- Jiayu ChenThird Affiliated Hospital of Guangzhou Medical University; Guangzhou Medical University
- Liujia FangThird Affiliated Hospital of Guangzhou Medical University; Guangzhou Medical University
Abstract
Introduction: Circulating vitamin D concentrations have been associated with the risk of type 2 diabetes (T2D). Magnesium has also been reported to be associated with lower T2D risk. Besides, magnesium is an essential cofactor for vitamin D activation. However, the effect of dietary magnesium intake on the association between vitamin D and the risk of T2D has not been studied comprehensively. Therefore, we designed this cross-sectional study to assess the effect modification of magnesium intake on the association between vitamin D and risk of T2D. Research Design and Methods: The present study analyzed data from the National Health and Nutrition Examination Survey (NHANES) continuously from 2007 to 2014, involving 10,249 participants. By having stratified participants based on magnesium intake category (low magnesium intake Results: In this cross-sectional study, the association of serum vitamin D with the incidence of T2D appeared to differ between the low magnesium intake group and the high magnesium intake group (OR: 0.968, 95%Cl: 0.919-1.02 vs. OR: 0.925, 95%Cl: 0.883-0.97). Furthermore, there was evidence of interaction between vitamin D levels and magnesium intake on decreasing the incidence of T2D (p-value for interaction = 0.001). Conclusions: The results of our study indicated that magnesium intake might affect the association of serum vitamin D with the risk of T2D. Such a finding requires further randomized controlled trials to provide more evidence.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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