Pre-diagnosis Cruciferous Vegetables and Isothiocyanates Intake and Ovarian Cancer Survival: A Prospective Cohort Study
Wei YF, Hao YY, Gao S, Li XQ, Liu FH, Wen ZY, Wang HY, Zhang S, Yan S, Luan M, Zhao YH, Gong TT, Wu QJ
Frontiers in nutrition · 18 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Independent funding
- Government
- Innovative Research Group Project of the National Natural Science Foundation of China
- Government
- National Natural Science Foundation of China
- Government
- China Postdoctoral Science Foundation
- University or hospital
- China Medical University
- Government
- Liaoning Revitalization Talents Program
- University or hospital
- Shengjing Hospital
- Grants
- Liaoning Revitalization Talents Program (82103914); National Natural Science Foundation of China (XLYC1907102); Liaoning Revitalization Talents Program (2017YFC0907404); Liaoning Revitalization Talents Program (XLYC1907102); National Natural Science Foundation of China (82073647); National Natural Science Foundation of China (81602918); National Natural Science Foundation of China (2017YFC0907404); Liaoning Revitalization Talents Program (82073647); National Natural Science Foundation of China (82103914); China Postdoctoral Science Foundation (2018M641752)
Based on 6 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2021-11-24 · Front Nutr · vol. 8 · p. 778031
- Publisher
- Frontiers Media
- Cited
- 20 citations · more than 82% of similar papers · 1.4× the field average
- References
- 61 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Genomics, phytochemicals, and oxidative stress · Garlic and Onion Studies · Ovarian cancer diagnosis and treatment
- Keywords
- Medicine, Hazard ratio, Interquartile range, Cruciferous vegetables, Body mass index, Proportional hazards model, Confidence interval, Internal medicine, Cohort study, Cohort, Prospective cohort study, Confounding, Cancer
13 authors
From CN
- Yifan WeiChina Medical University
- Yingying HaoChina Medical University
- Song GaoChina Medical University
- Xiuqin LiChina Medical University
- Fang-Hua LiuChina Medical University
- Zhao-Yan WenChina Medical University
Abstract
Background: The associations of the consumption of cruciferous vegetables (CVs) and their bioactive components, isothiocyanates (ITCs), with ovarian cancer (OC) mortality have been unclear, owing to limited studies and inconsistent findings. To date, no studies have evaluated these associations among Chinese patients with OC. This study aims to provide more evidence indicating the relationships of pre-diagnosis CVs and ITC intake with OC survival. Methods: We examined the associations of pre-diagnosis CV and ITC intake with OC mortality in a hospital-based cohort (n = 853) of Chinese patients with epithelial OC between 2015 and 2020. Pre-diagnosis dietary information was evaluated with a validated food frequency questionnaire. Deaths were ascertained until March 31, 2021 via medical records and active follow-up. The associations were examined with the Cox proportional hazards model, adjusted for potential confounders, and stratified by menopausal status, residual lesions, histological type, and body mass index (BMI). Results: During a median follow-up of 37.2 months (interquartile: 24.7-50.2 months), we observed 130 deaths. The highest tertile of total CV intake was associated with better survival than the lowest tertile intake [hazard ratio (HR) = 0.57, 95% confidence interval (CI) = 0.33-0.98, p trend T3VS.T1 = 0.59, 95% CI = 0.36-0.99, p trend = 0.06). Significant inverse associations were also observed for subgroup analyses stratified by menopausal status, residual lesions, histological type, and BMI, although not all associations showed statistical significance. Conclusion: Increasing pre-diagnosis consumption of CVs and ITCs was strongly associated with better survival in patients with OC.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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