Magnesium supplementation for glycemic status in women with gestational diabetes: a systematic review and meta-analysis
Tan X, Huang Y
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 7 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2021-12-15 · Gynecol Endocrinol · vol. 38 · issue 3 · pp. 202–206
- Publisher
- Informa
- Cited
- 9 citations · more than 45% of similar papers · 0.3× the field average
- References
- 37 works
- Access
- Paywalled
- Research areas
- Magnesium in Health and Disease · Gestational Diabetes Research and Management · Preterm Birth and Chorioamnionitis
- Keywords
- Gestational diabetes, Glycemic, Medicine, Meta-analysis, Diabetes mellitus, Obstetrics, Pregnancy, Internal medicine, Gynecology, Endocrinology, Gestation, Biology
- MeSH
- humans, diabetes, gestational, insulin resistance, magnesium, blood glucose, fasting, pregnancy, dietary supplements, female
2 authors
From CN
- Xiaoqing TanUniversity of Chinese Academy of Sciences
- Yi Huang · correspondingUniversity of Chinese Academy of Sciences
Abstract
Objective
The effect of magnesium supplementation on glycemic status in women with gestational diabetes remains controversial and this meta-analysis aims to explore the efficacy of magnesium supplementation for gestational diabetes.
Methods
We have searched PubMed, Excerpta Medica database, Web of science, Elton B. Stephens. Company, and Cochrane library databases. The meta-analysis included randomized controlled trials (RCTs) assessing the effect of magnesium supplementation for gestational diabetes and was performed using the random-effect model.
Results
Four RCTs were included in the meta-analysis. Overall, compared with placebo in gestational diabetes, magnesium supplementation was associated with significantly reduced fasting plasma glucose (standard mean difference [SMD] = -0.99; 95% confidence interval [CI] = -1.28 to -0.70; p p = .003), homeostasis model assessment of insulin resistance (SMD = -0.74; 95% CI = -1.10 to -0.39; p p = .008). In addition, low-density lipoprotein-cholesterol (SMD = -0.39; 95% CI = -0.73 to -0.04; p = .03) and total cholesterol (SMD = -0.62; 95% CI = -0.97 to -0.27; p = .0005) were also obviously decreased in the magnesium group than those in the control group.
Conclusion
Magnesium supplementation benefits glycemic control for gestational diabetes.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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