Rising Plasma Beta-Carotene Is Associated With Diminishing C-Reactive Protein in Patients Consuming a Dark Green Leafy Vegetable-Rich, Low Inflammatory Foods Everyday (LIFE) Diet
Schultz H, Ying GS, Dunaief JL, Dunaief DM
American journal of lifestyle medicine · 12 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Mechanisms only
- Intake measured by
- Intake biomarkers
Who paid for it
- Funding
- Independent funding
- Nonprofit
- Research to Prevent Blindness
- University or hospital
- Adele Niessen Endowed Chair
Based on 2 listed funder(s).
Publication
- Published
- 2019-12-21 · Am J Lifestyle Med · vol. 15 · issue 6 · pp. 634–643
- Publisher
- SAGE Publishing
- Cited
- 17 citations · more than 66% of similar papers · 0.8× the field average
- References
- 53 works
- Access
- Open access (repository copy)
- Research areas
- Antioxidant Activity and Oxidative Stress · Adipokines, Inflammation, and Metabolic Diseases · Nutritional Studies and Diet
- Keywords
- Medicine, Leafy vegetables, C-reactive protein, beta-Carotene, Inflammation, Internal medicine, Gastroenterology, Food science, Vitamin
4 authors
From US
- Hannah SchultzPenn Presbyterian Medical Center; University of Pennsylvania
- Gui‐Shuang YingPenn Presbyterian Medical Center; University of Pennsylvania
- Joshua L. DunaiefPenn Presbyterian Medical Center; University of Pennsylvania
- David M. Dunaief · correspondingCompass Oncology
Abstract
Chronic inflammation contributes to a number of chronic diseases and can be assessed with C-reactive protein (CRP). In this longitudinal retrospective chart review, we investigate whether patients intensively counseled to eat a specific diet high in dark green leafy vegetables, and thus high beta-carotene, have reductions in plasma high-sensitivity CRP (hsCRP). We term this the Low Inflammatory Foods Everyday (LIFE) diet. Forty-three patients in a community practice instructed to eat the LIFE diet met inclusion criteria. The CRP levels were measured at least twice over the course of up to a year. Adherence to the diet was objectively assessed by measurement of plasma beta-carotene, which is abundant in dark green leafy vegetables, and subjectively by serial interviews. The change in beta-carotene was inversely correlated with change in CRP (r = -0.68, P P P = .002) as compared with patients who were classified as nonadherent. These longitudinal findings suggest that adherence to the LIFE diet leads to increased beta-carotene and decreased CRP. Thus, this type of diet may reduce risk or severity of chronic diseases involving inflammation.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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