Ultra-Processed Food Consumption and Adult Diabetes Risk: A Systematic Review and Dose-Response Meta-Analysis
Moradi S, Hojjati Kermani MA, Bagheri R, Mohammadi H, Jayedi A, Lane MM, Asbaghi O, Mehrabani S, Suzuki K
Nutrients · 81 citations
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
Based on full-text disclosure statement.
Publication
- Published
- 2021-12-09 · Nutrients · vol. 13 · issue 12 · p. 4410
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 122 citations · more than 96% of similar papers · 4.8× the field average
- Impact
- Top 10% most cited in its field
- References
- 58 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Consumer Attitudes and Food Labeling · Nutritional Studies and Diet · Obesity, Physical Activity, Diet
- Keywords
- Meta-analysis, Medicine, Relative risk, Web of science, Cohort study, Type 2 Diabetes Mellitus, Observational study, Diabetes mellitus, Type 2 diabetes, Random effects model, Scopus, Internal medicine, MEDLINE, Environmental health, Confidence interval, Endocrinology, Biology
- MeSH
- humans, diabetes mellitus, type 2, risk, risk assessment, female, male, fast foods, observational studies as topic
9 authors
From IR, AU, JP
- Sajjad MoradiKermanshah University of Medical Sciences; Niroo Research Institute
- Mohammad Ali Hojjati KermaniMasih Daneshvari Hospital; Shahid Beheshti University of Medical Sciences
- Reza BagheriUniversity of Isfahan
- Hamed MohammadiTehran University of Medical Sciences
- Ahmad JayediTehran University of Medical Sciences
- Melissa M. LaneBarwon Health; Deakin University
Abstract
(1) Background: Recent individual studies have demonstrated that consumption of ultra-processed food (UPF) may be related to type two diabetes mellitus (T2DM). We aimed to synthesize the results from these individual studies by conducting an updated systematic review and meta-analysis of observational studies evaluating the association between UPF consumption and the risk of T2DM. (2) Methods: A systematic search was conducted using ISI Web of Science, PubMed/MEDLINE and Scopus electronic databases from inception up to August 2021. Data were extracted from five studies (one cross-sectional study and four cohort studies, totaling 230,526 adults from four different countries). Risk ratios (RR) of pooled results were estimated using a random-effects model. (3) Results: Our results revealed that higher UPF consumption was significantly associated with an increased risk of T2DM (RR = 1.74; 95% CI: 1.36, 2.22; I2 = 68.9%; p n = 5). Linear dose-response analysis indicated that each 10% increase in UPF consumption (kcal/d) was associated with a 15% higher risk of T2DM (RR = 1.15; 95% CI: 1.06, 1.26; I2 = 86.0%; p n = 5) among adults. Non-linear dose-response analysis demonstrated a positive linear association between UPF consumption and T2DM (pnonlinearity = 0.13, pdose-response n = 5) among adults. (4) Conclusions: A higher intake of UPF was significantly associated with an increased risk of T2DM. However, underlying mechanisms remain unknown and future experimental studies are warranted.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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