Role of Whole Grain Consumption in Glycaemic Control of Diabetic Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Xu D, Fu L, Pan D, Lu Y, Yang C, Wang Y, Wang S, Sun G
Nutrients · 24 citations
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- Government
- Postgraduate Research＆Practice Innovation Program of Jiangsu Province
Based on 1 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2021-12-27 · Nutrients · vol. 14 · issue 1 · p. 109
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 28 citations · more than 66% of similar papers · 0.8× the field average
- References
- 61 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Food composition and properties · Celiac Disease Research and Management · Nutritional Studies and Diet
- Keywords
- Medicine, Randomized controlled trial, Meta-analysis, Cochrane Library, Internal medicine, Insulin resistance, Area under the curve, Whole grains, Observational study, Plasma glucose, Insulin, Gastroenterology, Endocrinology, Food science, Chemistry
- MeSH
- humans, diabetes mellitus, blood glucose, diet, whole grains, glycemic control
8 authors
From CN
- Dengfeng XuSoutheast University
- Lingmeng FuZhejiang Provincial People's Hospital
- Da PanSoutheast University
- Yifei LüSoutheast University
- Chao YangSoutheast University
- Yuanyuan WangSoutheast University
Abstract
Background
Observational studies have indicated beneficial effects of whole grain consumption on human health. However, no evidence based on randomized controlled trials has been established. Our objective was to perform a systematic review and meta-analysis of randomized controlled trials to assess the effects of whole grain consumption in glycaemic control of diabetic patients.
Methods
A comprehensive search in four databases (Web of Science, Pubmed, Scopus and Cochrane library) was conducted to collect potential articles which measured the roles of whole grain consumption on glycaemic control up to October 2021.
Results
A total of 16 eligible trials involving 1068 subjects were identified to evaluate the pooled effect. The overall results indicated that compared with the control group, whole grain intake presented a significantly reduced concentration in fast plasma glucose (WMD = -0.51 mmol/L, 95% CI: -0.73, -0.28; I2 = 88.6%, p 2, 95% CI: -0.73, -0.04; I2 = 58.4%, p = 0.014), and glycosylated haemoglobin (WMD = -0.56%, 95% CI: -0.88, -0.25, I2 = 88.5%, p p = 0.120). In terms of incremental area under the curve (iAUC), data suggested that whole grain effected a significant decrease in Glucose-iAUC (WMD = -233.09 min × mmol/L, 95% CI: -451.62, -14.57; I2 = 96.1%, p p = 0.002), although only in a small number of studies. Of note, there is evidence for modest unexplained heterogeneity in the present meta-analysis.
Conclusion
Whole grain consumption confers a beneficial effect on glucose metabolism in patients with diabetes. Regrettably, since relevant studies were scarce, we failed to provide confident evidence of whole grain consumption on acute effects including Glucose-iAUC and Insulin-iAUC, which should be addressed in further trials.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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