Ultra-Processed Food Consumption and Adult Mortality Risk: A Systematic Review and Dose-Response Meta-Analysis of 207,291 Participants
Suksatan W, Moradi S, Naeini F, Bagheri R, Mohammadi H, Talebi S, Mehrabani S, Hojjati Kermani MA, Suzuki K
Nutrients · 107 citations
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
Based on full-text disclosure statement.
Publication
- Published
- 2021-12-30 · Nutrients · vol. 14 · issue 1 · p. 174
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 137 citations · more than 98% of similar papers · 6.1× the field average
- Impact
- Top 10% most cited in its field
- References
- 46 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Consumer Attitudes and Food Labeling · Nutritional Studies and Diet · Obesity, Physical Activity, Diet
- Keywords
- Meta-analysis, Medicine, Consumption (sociology), Environmental health, Food science, Internal medicine, Biology
- MeSH
- humans, cardiovascular diseases, cause of death, risk, cohort studies, feeding behavior, eating, adult, aged, aged, 80 and over, middle aged, female, male, young adult, fast foods
9 authors
From TH, IR, JP
- Wanich SuksatanChulabhorn Hospital; Chulabhorn Royal Academy; HRH Princess Chulabhorn College of Medical Science
- Sajjad Moradi · correspondingKermanshah University of Medical Sciences; Niroo Research Institute
- Fatemeh NaeiniUniversity of Tehran
- Reza BagheriUniversity of Isfahan
- Hamed MohammadiUniversity of Tehran
- Sepide TalebiUniversity of Tehran
Abstract
We performed a systematic review and dose-response meta-analysis of observational studies assessing the association between UPF consumption and adult mortality risk. A systematic search was conducted using ISI Web of Science, PubMed/MEDLINE, and Scopus electronic databases from inception to August 2021. Data were extracted from seven cohort studies (totaling 207,291 adults from four countries). Using a random-effects model, hazard ratios (HR) of pooled outcomes were estimated. Our results showed that UPF consumption was related to an enhanced risk of all-cause mortality (HR = 1.21; 95% CI: 1.13, 1.30; I2 = 21.9%; p 2 = 0.0%; p 2 = 0.0%; p = 0.022), but not cancer-cause mortality. Furthermore, our findings revealed that each 10% increase in UPF consumption in daily calorie intake was associated with a 15% higher risk of all-cause mortality (OR = 1.15; 95% CI: 1.09, 1.21; I2 = 0.0%; p Pnonlinearity = 0.879, Pdose-response = p Pnonlinearity = 0.868, Pdose-response = p Pnonlinearity = 0.774, Pdose-response = p < 0.001). It seems that higher consumption of UPF is significantly associated with an enhanced risk of adult mortality. Despite this, further experimental studies are necessary to draw a more definite conclusion.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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