Olive oil intake and cancer risk: A systematic review and meta-analysis
Markellos C, Ourailidou ME, Gavriatopoulou M, Halvatsiotis P, Sergentanis TN, Psaltopoulou T
PloS one · 57 citations
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
Based on full-text disclosure statement.
Publication
- Published
- 2022-01-11 · PLoS One · vol. 17 · issue 1 · p. e0261649
- Publisher
- Public Library of Science
- Cited
- 78 citations · more than 97% of similar papers · 4.4× the field average
- Impact
- Top 10% most cited in its field
- References
- 101 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Nutritional Studies and Diet · Edible Oils Quality and Analysis · Nuts composition and effects
- Keywords
- Medicine, Meta-analysis, Relative risk, Cohort study, Internal medicine, Cancer, Subgroup analysis, Mediterranean diet, Prospective cohort study, Confidence interval
- MeSH
- humans, neoplasms, breast neoplasms, gastrointestinal neoplasms, urologic neoplasms, risk factors, case-control studies, databases, factual, female, olive oil
6 authors
From GR
- Christos MarkellosNational and Kapodistrian University of Athens; Alexandra Hospital
- Maria-Eleni OurailidouNational and Kapodistrian University of Athens; Alexandra Hospital
- Maria GavriatopoulouNational and Kapodistrian University of Athens; Alexandra Hospital
- Panagiotis HalvatsiotisUniversity General Hospital Attikon
- Theodoros Ν. SergentanisNational and Kapodistrian University of Athens; Alexandra Hospital
- Theodora Psaltopoulou · correspondingNational and Kapodistrian University of Athens; Alexandra Hospital
Abstract
Background
Research evidence has established the beneficial effects of diet in cancer prevention; various epidemiological studies have suggested that olive oil component could play a role in decreasing cancer risk. This systematic review and meta-analysis aims to investigate the association between olive oil consumption, cancer risk and prognosis.
Methods
A systematic search was conducted in PubMed, EMBASE and Google Scholar databases (end-of-search: May 10, 2020). Pooled relative risk (RR) and 95% confidence intervals (95% CIs) were estimated with random-effects (DerSimonian-Laird) models. Subgroup analyses, sensitivity analyses and meta-regression analysis were also performed.
Results
45 studies were included in the meta-analysis; 37 were case-control (17,369 cases and 28,294 controls) and 8 were cohort studies (12,461 incident cases in a total cohort of 929,771 subjects). Highest olive oil consumption was associated with 31% lower likelihood of any cancer (pooled RR = 0.69, 95%CI: 0.62-0.77), breast (RR = 0.67, 95%CI: 0.52-0.86), gastrointestinal (RR = 0.77, 95%CI: 0.66-0.89), upper aerodigestive (RR = 0.74, 95%CI: 0.60-0.91) and urinary tract cancer (RR = 0.46, 95%CI: 0.29-0.72). Significant overall effects spanned both Mediterranean and non-Mediterranean participants, studies presenting a multivariate and a univariate analysis and all subgroups by study quality.
Conclusions
Olive oil consumption seems to exert beneficial actions in terms of cancer prevention. Additional prospective cohort studies on various cancer types and survivors, as well as large randomized trials, seem desirable.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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