Funded in part by Danone
Dietary cholesterol and egg intake are associated with the risk of gestational diabetes: a prospective study from Southwest China
Zhang Y, Lan X, Li F, Sun H, Zhang J, Li R, Gao Y, Dong H, Cai C, Zeng G
BMC pregnancy and childbirth · 9 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Food diaries or recalls
Who paid for it
- Funding
- Industry funded
- Company
- Danone
Based on 1 listed funder(s).
Publication
- Published
- 2022-01-17 · BMC Pregnancy Childbirth · vol. 22 · issue 1 · p. 45
- Publisher
- BioMed Central
- Cited
- 11 citations · more than 82% of similar papers · 1.6× the field average
- References
- 34 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Gestational Diabetes Research and Management · Birth, Development, and Health · Pregnancy and preeclampsia studies
- Keywords
- Medicine, Gestational diabetes, Cholesterol, Quartile, Odds ratio, Pregnancy, Prospective cohort study, Diabetes mellitus, Gestation, Dietary Cholesterol, Population, Internal medicine, Endocrinology, Obstetrics, Confidence interval, Environmental health, Biology
- MeSH
- humans, diabetes, gestational, cholesterol, dietary, triglycerides, diet surveys, logistic models, odds ratio, prospective studies, pregnancy, eggs, adult, china, female, cholesterol, ldl, cholesterol, hdl, maternal nutritional physiological phenomena
10 authors
From CN
- Yiqi ZhangSichuan University
- Xi LanSichuan University
- Fei LiSichuan University
- Hong SunSichuan University
- Ju ZhangChengdu Women's and Children's Central Hospital
- Run LiChengdu Women's and Children's Central Hospital
Abstract
Background
An increasing body of evidence suggests that cholesterol intake increases during pregnancy and may influence the risk of gestational diabetes mellitus (GDM). However, existing evidence remains controversial and limited. The present study aimed to determine the relation among dietary cholesterol, specifically egg consumption, in pregnant Chinese women and their risk of GDM.
Methods
A population-based study that included 1617 pregnant women was conducted in 2017. At baseline, dietary information was collected by 24-hour dietary recalls over three days. GDM was diagnosed by a 75 g 2-hr oral glucose tolerance test (OGTT) at 24-28 weeks of gestation. Logistic regression models were used to examine the associations of dietary cholesterol and egg intake with GDM. In addition, path analysis including cholesterol intake, plasma lipid profiles and GDM risk was conducted.
Results
The average total cholesterol intake was 340.8 mg/d, and cholesterol from eggs accounted for 59.2%. The odds ratio (OR) of GDM risk was 1.48 for the highest quartile of total cholesterol intake compared to the lowest quartile (95% CI 1.10-2.00; P trend = 0.015) after adjustment for potential risk factors for GDM. Moreover, cholesterol from eggs rather than from other foods was positively associated with incident GDM (OR=1.09, 95% CI 1.03-1.17). Each additional egg consumed per day was positively correlated with a higher risk of GDM (OR=1.32, 95% CI 1.11-1.58). Path analysis indicated that cholesterol intake not only increased the risk of GDM by elevating plasma total cholesterol (TC), but also increased the risk of GDM through other non hyperlipidemia pathways.
Conclusions
Maternal dietary cholesterol intake was significantly associated with incident GDM, and egg consumption was a major driver of the association in this population. More studies are needed to substantiate these findings and to explore the underlying mechanisms.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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