Intermittent Fasting in Weight Loss and Cardiometabolic Risk Reduction: A Randomized Controlled Trial
Chair SY, Cai H, Cao X, Qin Y, Cheng HY, Ng MT
The journal of nursing research : JNR · 41 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2022-01-20 · J Nurs Res · vol. 30 · issue 1 · p. e185
- Publisher
- Wolters Kluwer
- Cited
- 76 citations · more than 98% of similar papers · 7.5× the field average
- Impact
- Top 10% most cited in its field
- References
- 28 works
- Access
- Open access (free to publish) · CC-BY
- Research areas
- Dietary Effects on Health · Diet and metabolism studies · Genetics, Aging, and Longevity in Model Organisms
- Keywords
- Prediabetes, Overweight, Body mass index, Medicine, Waist, Weight loss, Randomized controlled trial, Internal medicine, Obesity, Intermittent fasting, Endocrinology, Diabetes mellitus, Type 2 diabetes
- MeSH
- humans, cardiovascular diseases, weight loss, fasting, risk reduction behavior, adult, overweight
6 authors
From HK, CN
- Sek Ying ChairChinese University of Hong Kong
- Hua “Linda” CaiHunan Provincial People's Hospital
- Xi Cao · correspondingChinese University of Hong Kong
- Yuelan QinHunan Provincial People's Hospital
- Ho Yu ChengChinese University of Hong Kong
- Michael Timothy Ng
Abstract
Background
Intermittent fasting is an effective approach to promote weight loss. The optimal model of intermittent fasting in achieving weight management and cardiometabolic risk reduction is an underexplored but important issue.
Purpose
This study was designed to examine the effects of alternate-day fasting (ADF) and 16/8 time-restricted fasting (16/8 TRF) on weight loss, blood glucose, and lipid profile in overweight and obese adults with prediabetes.
Methods
A randomized controlled trial was conducted on a sample of 101 overweight and obese adults with prediabetes. The participants were randomized into the ADF group (n = 34), 16/8 TRF group (n = 33), and control group (n = 34). The intervention lasted for 3 weeks. Data on body weight, body mass index, waist circumference, blood glucose, and lipid profile were collected at baseline, at the end of the intervention, and at the 3-month follow-up.
Results
The reductions in body weight, body mass index, and waist circumference in the ADF and 16/8 TRF groups were more significant than those in the control group across the study period (all ps < .05). Moreover, significant reductions on blood glucose and triglycerides were observed in the two intervention groups as well. Furthermore, the reductions in body weight and body mass index in the ADF group were more significant than those in the 16/8 TRF group (all ps < .001). However, differences on the changes in blood glucose, waist circumference, and low-density lipoprotein cholesterol between the two intervention groups were not significant.
Conclusions/implications for practice
The benefits of ADF and 16/8 TRF in promoting weight loss in overweight/obese adults with prediabetes were shown in this study. ADF was shown to have more-significant reduction effects on body weight and body mass index than 16/8 TRF. These findings indicate the potential benefit of integrating intermittent fasting regimens into normal dietary patterns to reduce the risk of diabetes and cardiovascular disease in this population.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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