Vitamin D Receptor (VDR) Gene Polymorphisms Modify the Response to Vitamin D Supplementation: A Systematic Review and Meta-Analysis
Usategui-Martín R, De Luis-Román DA, Fernández-Gómez JM, Ruiz-Mambrilla M, Pérez-Castrillón JL
Nutrients · 142 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2022-01-15 · Nutrients · vol. 14 · issue 2 · p. 360
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 199 citations · more than 99% of similar papers · 9.7× the field average
- Impact
- Top 10% most cited in its field
- References
- 48 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Vitamin D Research Studies · Menstrual Health and Disorders · Vitamin C and Antioxidants Research
- Keywords
- Calcitriol receptor, Meta-analysis, Vitamin D and neurology, Vitamin, Gene, Medicine, Endocrinology, Internal medicine, Genetics, Biology, Bioinformatics
- MeSH
- humans, vitamin d, receptors, calcitriol, genotype, polymorphism, genetic, alleles, dietary supplements, adolescent, adult, aged, middle aged, child, female, male, young adult, genetic association studies
5 authors
From ES
- Ricardo Usategui‐Martín · correspondingUniversidad de Valladolid; Instituto de Salud Carlos III
- Daniel-Antonio De Luis-RománUniversidad de Valladolid
- José María Fernández-GómezUniversidad de Valladolid
- Marta Ruiz‐MambrillaUniversidad de Valladolid
- José-Luis Pérez-Castrillón · correspondingUniversidad de Valladolid; Hospital Universitario Río Hortega
Abstract
The vitamin D receptor (VDR), a member of the nuclear receptor superfamily of transcriptional regulators, is crucial to calcitriol signalling. VDR is regulated by genetic and environmental factors and it is hypothesised that the response to vitamin D supplementation could be modulated by genetic variants in the VDR gene. The best studied polymorphisms in the VDR gene are Apal (rs7975232), BsmI (rs1544410), Taql (rs731236) and Fokl (rs10735810). We conducted a systematic review and meta-analysis to evaluate the response to vitamin D supplementation according to the BsmI, TaqI, ApaI and FokI polymorphisms. We included studies that analysed the relationship between the response to vitamin D supplementation and the genotypic distribution of these polymorphisms. We included eight studies that enrolled 1038 subjects. The results showed no significant association with the BsmI and ApaI polymorphisms (p = 0.081 and p = 0.63) and that the variant allele (Tt+tt) of the TaqI polymorphism and the FF genotype of the FokI variant were associated with a better response to vitamin D supplementation (p = 0.02 and p < 0.001). In conclusion, the TaqI and FokI polymorphisms could play a role in the modulation of the response to vitamin D supplementation, as they are associated with a better response to supplementation.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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