Dark Green Leafy Vegetable Intake, MTHFR Genotype, and Risk of Cutaneous Squamous Cell Carcinoma
Hughes MCB, Antonsson A, Rodriguez-Acevedo AJ, Liyanage UE, Green AC, van der Pols JC
Dermatology (Basel, Switzerland) · 4 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2022-01-01 · Dermatology · vol. 238 · issue 4 · pp. 657–661
- Publisher
- Karger Publishers
- Cited
- 7 citations · more than 76% of similar papers · 1.1× the field average
- References
- 16 works
- Access
- Open access (repository copy) · CC-BY-NC
- Research areas
- Folate and B Vitamins Research · Skin Protection and Aging · Antioxidant Activity and Oxidative Stress
- Keywords
- Methylenetetrahydrofolate reductase, Medicine, Relative risk, Genotype, Internal medicine, Confidence interval, Animal science, Skin cancer, Gastroenterology, Biology, Cancer, Genetics, Gene
- MeSH
- humans, vegetables, carcinoma, squamous cell, skin neoplasms, genetic predisposition to disease, folic acid, methylenetetrahydrofolate reductase (nadph2), risk factors, case-control studies, longitudinal studies, genotype, australia
6 authors
From AU, GB
- Maria Celia B. HughesQIMR Berghofer Medical Research Institute
- Annika AntonssonThe University of Queensland; QIMR Berghofer Medical Research Institute
- Astrid J. Rodriguez‐AcevedoThe University of Queensland
- Upekha E. LiyanageThe University of Queensland; QIMR Berghofer Medical Research Institute
- Adèle C. GreenQIMR Berghofer Medical Research Institute; Manchester Academic Health Science Centre; University of Manchester
- Jolieke C. van der PolsQueensland University of Technology; QIMR Berghofer Medical Research Institute
Abstract
Background
Evidence suggests that consumption of dark green leafy vegetables may influence the decrease in the risk of cutaneous squamous cell carcinoma (SCC). Dark green leafy vegetables contain folate as a main component among other nutrients; thus, we hypothesised that their possible observed protective effect on SCC, observed in previous studies, would be more evident in persons with specific genotypes related to folate metabolism.
Methods
Genotyping of methylenetetrahydrofolate reductase (MTHFR) gene variants rs1801133 (C677T) and rs1801131 (A1298C) was carried out for 1,128 participants in an Australian community-based longitudinal study of skin cancer. Dietary intakes were assessed through repeated Food Frequency Questionnaires (1992-1996), and all incident skin cancers were recorded in 1992-2007 and histologically confirmed. We assessed associations between intake of dark green leafy vegetables and SCC development in strata defined by genotype, by calculating relative risks (RRs) with 95% confidence intervals (CIs) using generalised linear models with negative binomial distribution and person-years of follow-up as offset.
Results
High versus low intake of dark green leafy vegetables was associated with a lower risk of SCC tumours in carriers of the C677T variant allele (RR = 0.42, 95% CI = 0.23-0.75), and within wild-type A1298C homozygotes (RR = 0.43, 95% CI = 0.22-0.85).
Conclusion
The protective effect of dark green leafy vegetables on cutaneous SCC may be genotype-dependent. Folate metabolism-related gene polymorphisms should be considered when assessing the relation of green leafy vegetables to cancer risk.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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