Association between magnesium intake and cognition in US older adults: National Health and Nutrition Examination Survey (NHANES) 2011 to 2014
Tao MH, Liu J, Cervantes D
Alzheimer's & dementia (New York, N. Y.) · 29 citations
How it was studied
- Design
- Cross-sectional study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- National Institutes of Health
- Government
- National Institute on Minority Health and Health Disparities
- Government
- NIMHD NIH HHS
- Grants
- National Institute on Minority Health and Health Disparities (U54MD006882); National Institutes of Health (U54 MD006882)
Based on 3 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2022-01-01 · Alzheimers Dement (N Y) · vol. 8 · issue 1 · p. e12250
- Publisher
- Elsevier BV
- Cited
- 34 citations · more than 94% of similar papers · 3.4× the field average
- Impact
- Top 10% most cited in its field
- References
- 51 works
- Access
- Open access (journal) · CC-BY-NC-ND
- Research areas
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments · Vitamin D Research Studies
- Keywords
- National Health and Nutrition Examination Survey, Quartile, Medicine, Confounding, Cognition, Dementia, Vitamin D and neurology, Gerontology, Confidence interval, Cognitive decline, Cross-sectional study, Vitamin, Demography, Environmental health, Internal medicine, Population, Pathology
3 authors
From US
- Meng‐Hua Tao · correspondingUniversity of North Texas; University of North Texas Health Science Center
- Jialiang LiuTemple University Health System; Temple University
- Diana CervantesUniversity of North Texas; University of North Texas Health Science Center
Abstract
Introduction
Identifying nutrition- and modifiable lifestyle-based risk factors for cognitive decline and dementia may contribute future primary prevention strategies. This study aimed to evaluate the associations between magnesium intake and cognition in older adults in the United States.
Methods
Based on the National Health and Nutrition Survey (NHANES) between 2011 and 2014, the study included 2508 participants aged 60 years and older. Linear regression models were used to examine the association of total magnesium intake with cognition.
Results
After adjusted demographic and other confounding factors, intakes of energy and total calcium, and serum vitamin D level, higher intake of total magnesium was independently associated with 0.15 higher global cognitive z-score (95% confidence interval, 0.02 to 0.28 for highest vs. lowest quartile, P trend = .037). The positive association of total magnesium intake with global cognition was primarily presented among women, non-Hispanic Whites, and those with sufficient serum vitamin D levels (≥50 nmol/L), although interactions were not significant. There were no clear linear associations for global cognition with serum vitamin D level.
Discussions
Our findings suggest that high magnesium intake alone may improve cognition in older adults, particularly among non-Hispanic Whites and subjects with sufficient levels of serum vitamin D. Further studies are needed to confirm the findings.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-ND).
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