Processed meat consumption and the risk of incident late-onset depression: a 12-year follow-up of the Salus in Apulia Study
Lampignano L, Sardone R, D'Urso F, Altamura M, Piccininni C, Griseta C, Bortone I, Castellana F, Zupo R, Donghia R, Guerra V, Resta E, Cisternino A, Caruso MG, Daniele A, De Pergola G, Bellomo A, Boeing H, Giannelli G, Panza F, Lozupone M
Age and ageing · 9 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Independent funding
- Government
- Ministero della Salute
- Government
- Italian Ministry of Health
Based on 2 listed funder(s).
Publication
- Published
- 2021-12-01 · Age Ageing · vol. 51 · issue 2
- Publisher
- Oxford University Press
- Cited
- 14 citations · more than 85% of similar papers · 1.7× the field average
- References
- 47 works
- Access
- Free to read
- Research areas
- Nutritional Studies and Diet · Agriculture Sustainability and Environmental Impact · Eating Disorders and Behaviors
- Keywords
- Medicine, Hazard ratio, Depression (economics), Incidence (geometry), Body mass index, Food group, Confidence interval, Proportional hazards model, Population, Demography, Internal medicine, Environmental health
- MeSH
- humans, diet, risk factors, follow-up studies, feeding behavior, depression, meat, middle aged
21 authors
From IT, DE
- Luisa LampignanoGastroenterology Hospital "Saverio de Bellis"
- Rodolfo SardoneGastroenterology Hospital "Saverio de Bellis"
- Francesca D’UrsoUniversity of Foggia
- Mario AltamuraUniversity of Foggia
- Carla PiccininniUniversity of Foggia
- Chiara GrisetaGastroenterology Hospital "Saverio de Bellis"
Abstract
Background
the possible relationship between dietary habits and the incidence of late-onset depression (LOD), defined as first depression onset at later age, is unclear.
Objective
to investigate the relationship between consumption of different food groups and incident LOD.
Design
longitudinal population-based study with a 12-year follow-up.
Setting
Castellana Grotte, Bari, Italy.
Subjects
five hundred and forty-six older subjects from the Salus in Apulia Study.
Methods
baseline data were recorded in 2003-06, and diagnostic data were recorded in 2013-18 at follow-up. Dietary intake was assessed with a food frequency questionnaire. Depressive disorders were assessed with the Structured Clinical Interview for DSM-IV Axis I Disorders. Subjects who already suffered from depression or other psychiatric disorders at baseline were excluded from the analysis. The association between LOD and single dietary determinants was examined by Cox regression analysis and then applying the hazard ratio (HR).
Results
subjects with incident LOD (n = 34) had lower global cognition and total cholesterol levels and a higher body mass index (BMI) at baseline. Only processed meat significantly increased the risk of incident LOD of about 10% by 5 g/day intake (HR adjusted for age, sex, education, multimorbidity and BMI: 1.13, 95% confidence intervals: 1.04-1.22). A similar relationship was found for single foods in the processed meat food group such as sausages, salami and mortadella and baked ham, but not for raw ham.
Conclusions
in midlife, a higher intake of processed meat was not only associated with an increased risk of cardiovascular- and metabolic-related chronic diseases in older age but also with an increased risk of developing LOD.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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