Dietary magnesium supplementation inhibits abdominal vascular calcification in an experimental animal model of chronic kidney disease
Leenders NHJ, Bos C, Hoekstra T, Schurgers LJ, Vervloet MG, Hoenderop JGJ
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 19 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Animal study (classified by our AI screen)
- Studied in
- Animals
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- Health~Holland
- Nonprofit
- Nierstichting
- Government
- Top Sector Life Sciences & Health
- Nonprofit
- Dutch Kidney Foundation
- Authors
- At least one author declares a financial tie to industry
- Grants
- Nierstichting (15OP02); Health~Holland (LSHM17034-HSGF)
Based on 4 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2022-02-01 · Nephrol Dial Transplant · vol. 37 · issue 6 · pp. 1049–1058
- Publisher
- Oxford University Press
- Cited
- 28 citations · more than 91% of similar papers · 2.8× the field average
- Impact
- Top 10% most cited in its field
- References
- 42 works
- Access
- Open access (hybrid journal) · CC-BY-NC
- Research areas
- Parathyroid Disorders and Treatments · Magnesium in Health and Disease · Kidney Stones and Urolithiasis Treatments
- Keywords
- Medicine, Kidney disease, Calcification, Animal model, Magnesium, Vascular disease, Internal medicine, Kidney, Disease, Endocrinology, Physiology
- MeSH
- aorta, abdominal, animals, humans, rats, rats, sprague-dawley, arteriosclerosis, disease models, animal, phosphates, calcium, magnesium, models, animal, dietary supplements, renal insufficiency, chronic, vascular calcification
6 authors
From NL
- Nicoline H. J. Leenders · correspondingRadboud University Nijmegen; Radboud University Medical Center; Radboud Institute for Molecular Life Sciences; Amsterdam University Medical Centers; Amsterdam Cardiovascular Sciences; Vrije Universiteit Amsterdam
- Caro BosRadboud University Nijmegen; Radboud University Medical Center; Radboud Institute for Molecular Life Sciences
- Tiny HoekstraAmsterdam University Medical Centers; Amsterdam Cardiovascular Sciences; Vrije Universiteit Amsterdam
- Leon J. SchurgersMaastricht University
- Marc G. VervloetAmsterdam University Medical Centers; Amsterdam Cardiovascular Sciences; Vrije Universiteit Amsterdam
- Joost G.J. HoenderopRadboud University Nijmegen; Radboud University Medical Center; Radboud Institute for Molecular Life Sciences
Abstract
Background
Vascular calcification is a key process involved in cardiovascular morbidity and mortality in patients with chronic kidney disease (CKD). Magnesium supplementation may counteract vascular calcification. In this study we aimed to determine whether increased dietary magnesium intake inhibits vascular calcification in CKD in vivo and explore the mechanisms underlying these effects.
Methods
Sprague Dawley rats were partially nephrectomized and fed a diet with high phosphate and either high or normal magnesium content for 16 weeks. The primary outcome was the tissue calcium content of the aorta in the high versus normal dietary magnesium group. In addition, we analysed plasma mineral concentrations, aortic vascular calcification identified with von Kossa staining, calcium apposition time and aortic expression of genes related to vascular calcification.
Results
The number of animals in the highest tissue calcium content tertile was significantly lower in the abdominal aorta [1 (10%) versus 6 (55%); P = .03] in the high versus normal dietary magnesium group, but did not differ in the aortic arch and thoracic aorta. Von Kossa staining and calcium apposition time corresponded to these results. The median tissue calcium content was not significantly different between the groups. Serum phosphate concentrations and expression of osteogenic markers in the aorta did not differ between the groups.
Conclusions
This study demonstrates that increased dietary magnesium inhibits abdominal vascular calcification in an experimental animal model of CKD in vivo. These are promising results for CKD patients and further study is needed to identify the mechanisms involved and to determine the clinical relevance in patients.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC).
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